JD McGarry - Diabetes, 2002 - Am Diabetes Assoc Readers of this journal do not need to be reminded of the explosive increase in obesity/type
2 diabetes syndromes and their attendant staggering public health costs that are currently afflicting
developed countries. Because of this alarming development and what it portends for the ... Cited by 612 - Related articles - All 9 versions
- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance
and pancreatic ß-cell failure and the precise sequence of events leading to the development
of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and ... Cited by 525 - Related articles - BL Direct - All 6 versions
- ►endojournals.org BH Goodpaster, J He, S Watkins, DE Kelley - Journal of Clinical …, 2001 - Endocrine Soc We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is associated
with insulin resistance and that this may be mediated by the oxidative capacity of muscle. Nine
sedentary lean (L) and 11 obese (O) subjects, 8 obese subjects with type 2 diabetes ... Cited by 296 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org AV Greco, G Mingrone, A Giancaterini, M Manco, M … - Diabetes, 2002 - Am Diabetes Assoc Obesity is a frequent cause of insulin resistance and poses a major risk for diabetes. Abnormal
fat deposition within skeletal muscle has been identified as a mechanism of obesity-associated
insulin resistance. We tested the hypothesis that dietary lipid deprivation may selectively ... Cited by 228 - Related articles - BL Direct - All 9 versions
- ►nih.gov AW Norris, L Chen, SJ Fisher, I Szanto, M … - Journal of Clinical …, 2003 - Am Soc Clin Investig Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones
(TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal
muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via ... Cited by 209 - Related articles - BL Direct - All 6 versions
E Ravussin, SR Smith - Ann NY Acad Sci, 2002 - pbrc.edu ABSTRACT: It is widely accepted that increasing adiposity is associated with insulin resistance
and increased risk of type 2 diabetes. The predominant para- digm used to explain this link is
the portal/visceral hypothesis. This hypothesis proposes that increased adiposity, ... Cited by 194 - Related articles - View as HTML - BL Direct - All 7 versions
- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in the setting of
high plasma free fatty acids or triglycerides. Alternatively, lipid overload results from mismatch
between free fatty acid import and utilization. Evidence from human studies and animal ... Cited by 197 - Related articles - BL Direct - All 8 versions
LS Szczepaniak, RL Dobbins, GJ Metzger, … - Magnetic …, 2003 - interscience.wiley.com Recent experimental data suggest that adiposity directly damages the heart by promoting ectopic
deposition of triglyceride, a process known as myocardial steatosis. The goal of this study was
to develop and validate proton magnetic resonance spectroscopy ( 1 H MRS) as an in ... Cited by 124 - Related articles - BL Direct - All 3 versions
BD Hegarty, SM Furler, J Ye, GJ Cooney, … - Acta Physiologica …, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 122 - Related articles - BL Direct - All 4 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and
the liver, and researchers have recently proposed two mechanisms by which excess adiposity
antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their ... Cited by 114 - Related articles - All 3 versions
