- ►ahajournals.org P Delafontaine, YH Song, Y Li - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc The vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor
(IGF-1R), and multiple binding proteins. This growth factor system exerts multiple physiologic
effects on the vasculature through both endocrine and autocrine/paracrine mechanisms. ... Cited by 141 - Related articles - BL Direct - All 9 versions
V Asnaghi, C Gerhardinger, T Hoehn, A Adeboje, M … - Diabetes, 2003 - Am Diabetes Assoc We tested the hypothesis that the apoptosis of inner retina neurons and increased expression
of glial fibrillary acidic protein (GFAP) observed in the rat after a short duration of diabetes are
mediated by polyol pathway activity. Rats with 10 weeks of streptozotocin-induced ... Cited by 105 - Related articles - BL Direct - All 4 versions
M Lorenzi, C Gerhardinger - Diabetologia, 2001 - Springer Important knowledge has been gained during the last decade on how to delay the onset and
progression of diabetic retinopathy by primary treatment of the un- derlying diabetic state. The
value of tight glycaemic control, strongly suggested by the pioneer prospec- tive study of ... Cited by 98 - Related articles - BL Direct - All 3 versions
C Gerhardinger, MB Costa, MC Coulombe, I Toth, T … - … ophthalmology & visual …, 2005 - ARVO RESULTS. Gene expression profiling identified 78 genes as differentially expressed in diabetic
Müller cells. One third of these genes were associated with inflammation, including a large cluster
(18% of the differentially expressed genes) of acute-phase response proteins: 2 - ... Cited by 75 - Related articles - All 6 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell types when intracellular
glucose concentrations are high, and it can generate cellular stress through several
mechanisms. The role of the polyol pathway in the pathogenesis of diabetic retinopathy ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►nih.gov J Ruberte, E Ayuso, M Navarro, A … - Journal of Clinical …, 2004 - Am Soc Clin Investig IGF-1 has been associated with the pathogenesis of diabetic retinopathy, although its role is
not fully understood. Here we show that normoglycemic/normoinsulinemic transgenic mice overexpressing
IGF-1 in the retina developed most alterations seen in human diabetic eye disease. A ... Cited by 61 - Related articles - BL Direct - All 5 versions
R Simó, A Lecube, RM Segura, J Garcı́a Arumí, C … - American journal of …, 2002 - Elsevier RESULTS: Vitreal levels of both free IGF-1 and VEGF were higher in diabetic patients with PDR
than in control subjects (P < .01, and P < .0001, respectively). After adjusting for total intravitreous
protein concentration, VEGF (ng/mg of proteins) remained significantly higher in diabetic ... Cited by 51 - Related articles - All 16 versions
J Zhang, C Gerhardinger, M Lorenzi - Diabetes, 2002 - Am Diabetes Assoc Diabetic retinal microangiopathy is characterized by increased permeability, leukostasis,
microthrombosis, and apoptosis of capillary cells, all of which could be caused or compounded
by activation of complement. In this study, we observed deposition of C5b-9, the terminal ... Cited by 48 - Related articles - BL Direct - All 4 versions
J ŽDYCHOVÁ, R Komers - Physiol. Res, 2005 - biomed.cas.cz Summary In addition to a number of deleterious effects on cellular integrity and functions, diabetic
metabolic milieu has been implicated in a rapidly growing number of alterations in signal
transduction. In this review we focus on Akt kinase physiology, its alterations in diabetes ... Cited by 43 - Related articles - View as HTML - All 5 versions
R Simo, E Carrasco, M Garcia-Ramirez, C … - Current Diabetes …, 2006 - ingentaconnect.com Abstract: Diabetic retinopathy continues to be the leading cause of legal blindness among
working-age individuals. The earliest histological features of diabetic retinopathy include neuroretinal
damage, capillary basement membrane thickening, loss of pericytes and loss of ... Cited by 37 - Related articles - BL Direct - All 2 versions
