- ►aacrjournals.org KE O'Reilly, F Rojo, QB She, D Solit, GB … - Cancer Research, 2006 - AACR Activation of phosphoinositide-3-kinase (PI3K)/Akt/mTOR signaling through
mutation of pathway components as well as through activation of upstream
signaling molecules occurs in a majority of cancers contributing to ... Cited by 336 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is
elevated in various insulin-resistant states including type 2 diabetes, obesity,
cancer, and HIV-associated lipodystrophy. To determine the role of IL-6 in ... Cited by 166 - Related articles - BL Direct - All 4 versions
PJ Klover, TA Zimmers, LG Koniaris, RA … - Diabetes, 2003 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines associated with
the insulin resistance of obesity and type 2 diabetes. There is, however, little
direct evidence in vivo for a causative role of IL-6 in insulin resistance. ... Cited by 165 - Related articles - BL Direct - All 4 versions
P Gual, Y Le Marchand-Brustel, JF Tanti - Biochimie, 2005 - Elsevier This review will provide insight on the current understanding of the regulation
of insulin signaling in both physiological and pathological conditions through
modulations that occur with regards to the functions of the insulin ... Cited by 159 - Related articles - All 3 versions
- ►jbc.org F Tremblay, A Marette - Journal of Biological Chemistry, 2001 - ASBMB Amino acids have emerged as potent modulators of the mTOR/p70 S6 kinase pathway.
The involvement of this pathway in the regulation of insulin-stimulated glucose
transport was investigated in the present study. Acute exposure (1 h) to a ... Cited by 154 - Related articles - BL Direct - All 3 versions
Y Zick - Trends in cell biology, 2001 - Elsevier Insulin resistance refers to a decreased capacity of circulating insulin to
regulate nutrient metabolism. It is associated with the development of type 2
diabetes – an ever-increasing epidemic of the 21st century. Recent ... Cited by 156 - Related articles - BL Direct - All 8 versions
- ►nih.gov R Zhande, JJ Mitchell, J Wu, XJ Sun - Molecular and Cellular Biology, 2002 - Am Soc Microbiol Insulin receptor substrate 1 (IRS-1) plays an important role in the insulin
signaling cascade. In vitro and in vivo studies from many investigators have
suggested that lowering of IRS-1 cellular levels may be a mechanism of ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►jbc.org MW Greene, H Sakaue, L Wang, DR Alessi, … - Journal of Biological Chemistry, 2003 - ASBMB Ser/Thr phosphorylation of insulin receptor substrate-1 (IRS-1) is a negative
regulator of insulin signaling. One potential mechanism for this is that Ser/Thr
phosphorylation decreases the ability of IRS-1 to be ... Cited by 116 - Related articles - BL Direct - All 4 versions
- ►jbc.org L Rui, TL Fisher, J Thomas, MF White - Journal of Biological Chemistry, 2001 - ASBMB Insulin and insulin-like growth factor-1 (IGF-1) regulate metabolism and body
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- ►nih.gov JK Kim, RE Gimeno, T Higashimori, HJ Kim, H … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig 1 Department of Internal Medicine, Yale University School of Medicine, New
Haven, Connecticut, USA. 2 Millennium Pharmaceuticals Inc., Cambridge,
Massachusetts, USA. 3 Whitehead Institute for Biomedical Research, ... Cited by 113 - Related articles - BL Direct - All 11 versions
