- ►nih.gov [PDF] TA Kinard, G De Vries, A Sherman, LS Satin - Biophysical journal, 1999 - Elsevier Glucose triggers bursting activity in pancreatic islets, which mediates the Ca 2+ uptake that
triggers insulin secretion. Aside from the channel mechanism responsible for bursting, which remains
unsettled, it is not clear whether ... Cited by 58 - Related articles - BL Direct - All 12 versions
P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro are still unclear.
Because glucose metabolism and changes in cytosolic free Ca 2+ ([Ca 2+ ] c ) in β-cells play a key
role in the control of insulin ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►nih.gov MG Pedersen, R Bertram, A Sherman - Biophysical journal, 2005 - Elsevier Insulin secretion from pancreatic β-cells is pulsatile with a period of 5–10 min and is believed
to be responsible for plasma insulin oscillations with similar frequency. To observe an overall
oscillatory insulin profile it is ... Cited by 31 - Related articles - BL Direct - All 14 versions
CS Nunemaker, M Zhang, DH Wasserman, OP … - Diabetes, 2005 - Am Diabetes Assoc Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic
glucose-dependent intracellular calcium concentration ([Ca 2+ ] i ) pulsatility of individual
islets. In isolation, islets ... Cited by 24 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org JM Lin, ME Fabregat, R Gomis, P Bergsten - Diabetes, 2002 - Am Diabetes Assoc Plasma insulin in healthy subjects shows regular oscillations, which are important for the
hypoglycemic action of the hormone. In individuals with type 2 diabetes, these regular variations
are altered, which has been ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SH Song, L Kjems, R Ritzel, SM McIntyre, ML … - Journal of Clinical …, 2002 - Endocrine Soc Insulin is secreted in discrete bursts. These pulses are also present when individual or groups of
islets are perifused. Interpretation of the measured frequency and magnitude of pulsatile hormone
secretion requires an examination ... Cited by 20 - Related articles - BL Direct - All 4 versions
P Bergsten, J Westerlund, P Liss, PO Carlsson - Diabetes, 2002 - Am Diabetes Assoc The role of metabolism in the generation of plasma insulin oscillations was investigated by
simultaneous in vivo recordings of oxygen tension (pO 2 ) in the endocrine and exocrine pancreas and
portal blood insulin concentrations ... Cited by 17 - Related articles - BL Direct - All 4 versions
S Speier, A Gjinovci, A Charollais, P Meda, M Rupnik - Diabetes, 2007 - Am Diabetes Assoc We studied the effect of gap junctional coupling on the excitability of β-cells in slices of
pancreas, which provide a normal environment for islet cells. The electrophysiological properties of
β-cells from mice (C57Bl/6 ... Cited by 15 - Related articles - BL Direct - All 5 versions
L Sha, JH Szurszewski - Neuroscience letters, 1999 - Elsevier The aim of this study was to determine whether leptin modulates neuronal activity in intrapancreatic
ganglion neurons. Intracellular recordings were made in dog pancreatic neurons. Recombinant mouse
leptin (313 nM) was added by ... Cited by 7 - Related articles - All 4 versions
RC Earnhardt, JD Veldhuis, G Cornett, JB … - Annals of surgery, 2002 - pubmedcentral.nih.gov Pulsatile and invariant basal insulin secretion was studied in normal dogs (n = 4) and three canine
models of the anatomical alterations of pancreas transplantation: 70% partial pancreatectomy (PPX, n
= 4), partial pancreatectomy with ... Cited by 5 - Related articles - BL Direct - All 4 versions
