- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of
glucagon-like peptide-1 (GLP-1) receptor-mediated signal transduction in the
pancreatic β-cell. Although GLP-1 is established to be a cAMP-elevating ... Cited by 127 - Related articles - BL Direct - All 6 versions
GC Yaney, BE Corkey - Diabetologia, 2003 - Springer Increases in glucose or fatty acids affect metabolism via changes in long-chain
acyl-CoA formation and chronically elevated fatty acids increase total cellular
CoA. Understanding the response of pancreatic beta cells to increased ... Cited by 115 - Related articles - BL Direct - All 3 versions
- ►bcell.org [PDF] PE MacDonald, W El-kholy, MJ Riedel, AMF … - Diabetes, 2002 - Am Diabetes Assoc The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense
interest because of the potential clinical relevance of this peptide. Produced
in intestinal L-cells through posttranslational processing of the ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Roduit, P Masiello, SP Wang, H Li, GA … - Diabetes, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the
β-cell adapts its secretory capacity in obesity and diabetes. In addition,
hormone-sensitive lipase (HSL) is expressed in β-cells and may provide ... Cited by 74 - Related articles - BL Direct - All 5 versions
H Mulder, M Sörhede-Winzell, JA Contreras, M … - Journal of Biological Chemistry, 2003 - ASBMB Lipid metabolism plays an important role in glucose homeostasis under normal and
pathological conditions. In adipocytes, skeletal muscle, and pancreatic
β-cells, lipids are mobilized from acylglycerides by the hormone-sensitive ... Cited by 61 - Related articles - BL Direct - All 5 versions
MC Lawrence, HS Bhatt, RA Easom - Diabetes, 2002 - Am Diabetes Assoc Currently there is intense interest to define the mechanism of action of
glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including
insulin gene transcription. In this study, GLP-1 (100 nmol/l), in the ... Cited by 46 - Related articles - BL Direct - All 5 versions
H Mulder, S Yang, MS Winzell, C Holm, B … - Diabetes, 2004 - Am Diabetes Assoc Lipids may serve as coupling factors in K ATP -independent glucose sensing in
β-cells. We have previously demonstrated that β-cells harbor lipase
activities, one of which is the hormone-sensitive lipase. Whether β-cell ... Cited by 39 - Related articles - BL Direct - All 5 versions
NJ Pyne, BL Furman - Diabetologia, 2003 - Springer Cyclic nucleotide phosphodiesterases (PDEs) com- prise a family of enzymes
(PDE1-PDE11) which hy- drolyse cyclic AMP and cyclic GMP to their biologi- cally
inactive 5′ derivatives. Cyclic AMP is an impor- tant physiological ... Cited by 36 - Related articles - BL Direct - All 5 versions
