- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis of
obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin ... Cited by 199 - Related articles - BL Direct - All 7 versions
DR Laybutt, H Kaneto, W Hasenkamp, S Grey, JC … - Diabetes, 2002 - Am Diabetes Assoc Hypertrophy is one mechanism of pancreatic β-cell growth and is seen as an important compensatory
response to insulin resistance. We hypothesized that the induction of protective genes contributes
to the survival of enlarged ( ... Cited by 112 - Related articles - BL Direct - All 5 versions
J Sturis, CF Gotfredsen, J Rømer, B Rolin, … - British journal of …, 2003 - pubmedcentral.nih.gov When liraglutide was dosed sc at 150 μg kg −1 bid for 6 weeks in ZDF rats 6–8 weeks of age at
study start, diabetes development was markedly attenuated. Blood glucose was approximately 12 mM
lower compared to vehicle ... Cited by 71 - Related articles - BL Direct - All 4 versions
D Chen, MW Wang - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com The increasing worldwide incidence of diabetes in adults constitutes a global public health burden.
It is predicted that by 2025, India, China and the United States will have the largest number of
people with diabetes [1]. According ... Cited by 43 - Related articles - All 4 versions
LC Pickavance, CL Brand, K Wassermann … - British journal of …, 2005 - pubmedcentral.nih.gov Insulin sensitivity was improved equally by RAGA and PIO in fa/fa rats subjected to both prevention
and intervention treatments (eg, prevention HOMA-IR: −71 and −72%, respectively), as was
hyperglycaemia (both −68%). BF ... Cited by 35 - Related articles - All 5 versions
M Prentki, CJ Nolan - 临床研究杂志, 2006 - journal.shouxi.net The major focus of this Review is on the mechanisms of islet ? cell failure in the pathogenesis of
obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of ? cell
compensation for insulin ... Cited by 31 - Related articles - Cached - All 2 versions
C Kjørholt, MC Åkerfeldt, TJ Biden, DR Laybutt - Diabetes, 2005 - Am Diabetes Assoc The β-cell is a highly specialized cell with a unique differentiation that optimizes
glucose-induced insulin secretion (GIIS). Here, we evaluated changes in gene expression that
accompany β-cell dysfunction in ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►ebmonline.org CL Winter, JS Lange, MG Davis, GS Gerwe, TR … - Experimental Biology and …, 2005 - SEBM The molecular basis of insulin resistance, a major risk factor for development of Type II diabetes,
involves defective insulin signaling. Insulin-mediated signal transduction is negatively regulated
by the phosphotyrosine phosphatase, ... Cited by 23 - Related articles - All 7 versions
- ►endocrinology-journals.org KE Garnett, P Chapman, JA Chambers, ID … - Journal of molecular …, 2005 - Soc Endocrinology The ß-cell failure that characterises type 2 diabetes is likely to involve altered expression of
many genes. We aimed to identify global changes in gene expression underlying ß-cell dysfunction in
pre-diabetic Zucker Diabetic Fatty ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►physiology.org TT Goh, TM Mason, N Gupta, A So, TKT … - American Journal of …, 2007 - Am Physiological Soc We determined the effect of 48-h elevation of plasma free fatty acids (FFA) on insulin secretion
during hyperglycemic clamps in control female Wistar rats (group a) and in the following female rat
models of progressive -cell ... Cited by 18 - Related articles - BL Direct - All 5 versions
