- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM Grodsky - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other metabolites
including free fatty acids (FFA). Recent evidence suggests that common stress-activated ... Cited by 598 - Related articles - BL Direct - All 18 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrinology, 2002 - Endocrine Soc Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on ß-cell function, respectively
referred to as glucotoxicity and lipotoxicity. Over time, both contribute to the progressive deterioration
of glucose homeostasis characteristic of type 2 diabetes. The mechanisms of glucotoxicity ... Cited by 329 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical …, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic β
cells, causing impaired insulin secretion. IL-1β is a proinflammatory cytokine acting during the
autoimmune process of type 1 diabetes. IL-1β inhibits β cell function and promotes Fas- ... Cited by 329 - Related articles - BL Direct - All 7 versions
- ►pnas.org LL Listenberger, X Han, SE Lewis, S … - Proceedings of the …, 2003 - National Acad Sciences Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic
β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative toxicity
of two common dietary long chain fatty acids is related to channeling of these lipids to ... Cited by 314 - Related articles - BL Direct - All 10 versions
RP Robertson, J Harmon, POT Tran, V Poitout - Diabetes, 2004 - Am Diabetes Assoc The relentless decline in β-cell function frequently observed in type 2 diabetic patients, despite
optimal drug management, has variously been attributed to glucose toxicity and lipotoxicity. The
former theory posits hyperglycemia, an outcome of the disease, as a secondary force that ... Cited by 202 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org K Maedler, GA Spinas, R Lehmann, P Sergeev, M … - Diabetes, 2001 - Am Diabetes Assoc In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may represent one of the
essential pro-apoptotic pathways leading to a loss of pancreatic ß-cells. In the advanced stages
of type 2 diabetes, a decline in ß-cell mass is also observed, but its mechanism is not ... Cited by 195 - Related articles - BL Direct - All 5 versions
- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in the setting of
high plasma free fatty acids or triglycerides. Alternatively, lipid overload results from mismatch
between free fatty acid import and utilization. Evidence from human studies and animal ... Cited by 197 - Related articles - BL Direct - All 8 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R Roduit, S … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs)
together with hyperglycemia are synergistic in causing islet ß-cell damage because high glucose
inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture of ... Cited by 174 - Related articles - BL Direct - All 5 versions
K Maedler, J Oberholzer, P Bucher, GA Spinas, MY … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different
glucose concentrations on human β-cell turnover and secretory function. Exposure of ... Cited by 150 - Related articles - BL Direct - All 5 versions
MY Donath, J Størling, K Maedler, T Mandrup- … - Journal of Molecular …, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute
or relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to
autoimmunity. In type 2 diabetes β-cell death occurs as the combined consequence of ... Cited by 145 - Related articles - BL Direct - All 3 versions
