- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus
in ro- dents and possibly in humans. Clarification of the regulation of beta-cell death could indicate
novel sites for therapeutic intervention in Type I (insulin- dependent) diabetes mellitus. ... Cited by 323 - Related articles - BL Direct - All 6 versions
T Borsello, PGH Clarke, L Hirt, A Vercelli, M Repici, DF … - Nature medicine, 2003 - neuronlab.org Although ischemic stroke is the third most common cause of death in the United States and
Europe, the only currently approved med- ical treatment is administration of intravenous recombinant
tissue plasminogen activator within 3 h of stroke onset, aimed at restor- ing cerebral blood ... Cited by 258 - Related articles - BL Direct - All 22 versions
- ►uniroma2.it [PDF] DA Dickinson, HJ Forman - Biochemical pharmacology, 2002 - Elsevier Low molecular weight thiol-containing compounds have an essential role in many biochemical
and pharmacological reactions due to the ease with each they are oxidized, and the rapidity
with which they can be regenerated. Thioredoxin and glutathione (GSH) are two of the ... Cited by 211 - Related articles - All 7 versions
GPH Dietz, M Bδhr - Molecular and Cellular Neuroscience, 2004 - Elsevier In recent years, vast amounts of data on the mechanisms of neural de- and regeneration have
accumulated. However, only in disproportionally few cases has this led to efficient therapies
for human patients. Part of the problem is to deliver cell death-averting genes or gene ... Cited by 202 - Related articles - All 3 versions
YH Lee, J Giraud, RJ Davis, MF White - Journal of Biological Chemistry, 2003 - ASBMB Activation of the c-Jun N-terminal kinase (JNK) by proinflammatory cytokines inhibits insulin
signaling, at least in part, by stimulating phosphorylation of rat/mouse insulin receptor substrate
1 (Irs1) at Ser 307 (Ser 312 in human IRS1). Here we show that JNK mediated feedback ... Cited by 186 - Related articles - BL Direct - All 6 versions
DA Dickinson, HJ Forman - Ann NY Acad Sci, 2002 - interscience.wiley.com Abstract: The mechanisms of thiol metabolism and chemistry have particular relevance to both
cellular defenses against toxicant exposure and to redox signaling. Here, we will focus on glutathione
(GSH), the major endogenous low- molecular-weight nonprotein thiol synthesized de ... Cited by 181 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the mechanisms
leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, ... Cited by 174 - Related articles - BL Direct - All 10 versions
H Kaneto, Y Nakatani, T Miyatsuka, D Kawamori, T … - Nature medicine, 2004 - nature.com The JNK pathway is known to be activated in several tissues in the diabetic state, and is possibly
involved in the development of insulin resistance and suppression of insulin biosynthesis. Here
we show a potential new therapy for diabetes using cell-permeable JNK-inhibitory ... Cited by 167 - Related articles - BL Direct - All 4 versions
H Brooks, B Lebleu, E Vivès - Advanced drug delivery reviews, 2005 - Elsevier Peptides are emerging as attractive drug delivery tools. The HIV Tat-derived peptide is a small
basic peptide that has been successfully shown to deliver a large variety of cargoes, from small
particles to proteins, peptides and nucleic acids. The 'transduction domain' or region ... Cited by 159 - Related articles - All 4 versions
- ►physiology.org K Sakamoto, LJ Goodyear - Journal of Applied Physiology, 2002 - Am Physiological Soc Physical exercise is a significant stimulus for the regulation of multiple metabolic and transcriptional
processes in skeletal muscle. For example, exercise increases skeletal muscle glucose
uptake, and, after exercise, there are increases in the rates of both glucose uptake and ... Cited by 152 - Related articles - BL Direct - All 3 versions
