- ►jbc.org Y Lin, AH Berg, P Iyengar, TKT Lam, A Giacca, TP … - Journal of Biological …, 2005 - ASBMB Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The consequences
of exposure of endothelial cells to hyperglycemia are well established. However, little is known
about how adipocytes respond to both acute as well as chronic exposure to physiological ... Cited by 152 - Related articles - All 6 versions
- ►jbc.org B Lu, D Ennis, R Lai, E Bogdanovic, R Nikolov, L … - Journal of Biological …, 2001 - ASBMB Vanadate (sodium orthovanadate), an inhibitor of phosphotyrosine phosphatases (PTPs), mimics
many of the metabolic actions of insulin in vitro and in vivo. The potential of vanadate to stimulate
glucose transport independent of the early steps in insulin signaling prompted us to test ... Cited by 47 - Related articles - BL Direct - All 4 versions
C González, A Alonso, NA Grueso, F Dı́az, MM Esteban … - Steroids, 2002 - Elsevier The role of 17β-estradiol in the early steps of insulin action is only partially known, although its
effect on glucose homeostasis has been reported. In this paper, we attempt to prove the influence
of 17β-estradiol on the insulin receptor of ovariectomized rats treated with different ... Cited by 34 - Related articles - All 4 versions
JE Clampit, JL Meuth, HT Smith, RM Reilly, MR … - … and Biophysical Research …, 2003 - Elsevier Protein-tyrosine phosphatase-1B (PTP1B) has been implicated as a negative regulator of insulin
signaling. PTP1B dephosphorylates the insulin receptor and insulin receptor substrates
(IRS-1/2), inhibiting the insulin-signaling pathway. PTP1B has been reported to be ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►eje.org [PDF] J Buren, HX Liu, J Lauritz, JW Eriksson - European journal of endocrinology, 2003 - eje.org Objective: The purpose of this study was to investigate the cellular effects of long-term exposure
to high insulin and glucose levels on glucose transport and insulin signalling proteins. Design
and methods: Rat adipocytes were cultured for 24h in different glucose concentrations ... Cited by 28 - Related articles - BL Direct - All 11 versions
KM Beard, H Lu, K Ho, IG Fantus - Diabetes, 2006 - Am Diabetes Assoc An increase in bradykinin has been suggested to contribute to the enhanced insulin sensitivity
observed in the presence of ACE inhibitors. To investigate a potential direct, nonvascular effect
on an insulin target tissue, the effect of bradykinin on glucose uptake and insulin ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►physoc.org P Ordóñez, M Moreno, A Alonso, R Fernández, … - Experimental …, 2007 - Physiological Soc It has been reported that in streptozotocin (STZ)-induced diabetes, hyperglycaemia leads to progressive
insulin resistance of the peripheral tissues. In this study, we tried to elucidate the effects of hyperglycaemia
on insulin sensitivity and insulin signalling in ovariectomized (STZ)-induced diabetic rats. ... Cited by 10 - Related articles - BL Direct - All 7 versions
R Somwar, X Fang, G Sweeney - Drug Discovery Today: Disease Models, 2005 - Elsevier Type 2 diabetes, also previously known as adult-onset or non-insulin-dependent diabetes mellitus
(NIDDM), accounts for 90% of all cases of diabetes [1]. In type 2 diabetes, hyperglycemia occurs
owing to insulin resistance in skeletal muscle, liver and fat cells and a relative failure of ... Cited by 5 - Related articles
GE Lim, GJ Huang, N Flora, D LeRoith, CJ Rhodes, PL … - Endocrinology, 2009 - Endocrine Soc Insulin resistance and type 2 diabetes mellitus are associated with impaired postprandial secretion
of glucagon-like peptide-1 (GLP-1), a potent insulinotropic hormone. The direct effects of insulin
and insulin resistance on the L cell are unknown. We therefore hypothesized that the L ... Cited by 5 - Related articles - All 3 versions
- ►nih.gov X Wu, L Zhu, A Zilbering, K Mahadev, H … - Antioxidants & redox …, 2005 - liebertonline.com 1 Dorrance H. Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic
Diseases, Department of Medicine, Jeffer- son Medical College of Thomas Jefferson
University, Philadelphia, PA. 2 Division of Endocrinology, Zhongshan Hospital, Shanghai ... Cited by 3 - Related articles - All 2 versions
