- ►physiology.org MF White - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc Although a full understanding of insulin/insulin-like growth factor (IGF) action
is evolving, the discovery of insulin receptor substrate (IRS) proteins and
their role to link cell surface receptors to the intracellular signaling ... Cited by 390 - Related articles - BL Direct - All 11 versions
H Kojima, M Fujimiya, K Matsumura, P … - Nature medicine, 2003 - nature.com To explore induced islet neogenesis in the liver as a strategy for the treatment
of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the
pancreatic duodenal homeobox-1 gene (Ipf1; also known as Pdx-1) to ... Cited by 232 - Related articles - BL Direct - All 3 versions
S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 123 - Related articles - BL Direct - All 6 versions
- ►nih.gov K Minami, M Okuno, K Miyawaki, A Okumachi, … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Although several studies have suggested that insulin-secreting cells can be
generated in vitro from cells residing in adult exocrine pancreas, neither the
origin of these cells nor their precise insulin secretory properties was ... Cited by 74 - Related articles - BL Direct - All 11 versions
- ►nih.gov R Gasa, C Mrejen, N Leachman, M Otten, M … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences In the developing pancreas, the basic helix–loop–helix (bHLH) protein
Neurogenin3 (Ngn3) specifies which precursor cells ultimately will become
endocrine cells and initiates the islet differentiation program. NeuroD1, a ... Cited by 56 - Related articles - BL Direct - All 12 versions
S Efrat - Trends in molecular medicine, 2002 - Elsevier Replacement of the insulin-producing pancreatic islet β cells represents the
ultimate treatment for type 1 diabetes. Recent advances in islet transplantation
underscore the urgent need for developing alternatives to human tissue ... Cited by 51 - Related articles - All 4 versions
PA Halban - Nature cell biology, 2004 - uoguelph.ca In August 2004, the British government awarded a licence to the Newcastle
Fertility Centre for therapeutic cloning; generation of insulin-producing cells
to treat diabetes was mentioned as a major goal. Although the authorization ... Cited by 48 - Related articles - View as HTML - BL Direct - All 9 versions
A Auricchio, GP Gao, QC Yu, S Raper, VM … - Gene therapy, 2002 - ncbi.nlm.nih.gov To test whether hepatocytes engineered in vivo can serve as surrogate beta cells
by similarly secreting mature insulin in a glucose-sensitive manner, we prepared
adenoviral vectors encoding wild-type proinsulin (hIns-wt), a modified ... Cited by 43 - Related articles - BL Direct - All 3 versions
F Ris, E Hammar, D Bosco, C Pilloud, K … - Diabetologia, 2002 - Springer Aims/hypothesis. Human islet cells survive poorly in culture and are overgrown
by non-endocrine cells. The aims of this study were to sort human beta cells and
to develop approaches for their improved survival in culture. Methods. ... Cited by 38 - Related articles - BL Direct - All 4 versions
