- ►nih.gov S Xuan, T Kitamura, J Nakae, K Politi, Y … - Journal of Clinical …, 2002 - Am Soc Clin Investig Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory
increase of β cell mass and impaired glucose-dependent insulin release. β cell proliferation and
secretion are thought to be regulated by signaling through receptor tyrosine kinases. In ... Cited by 117 - Related articles - BL Direct - All 11 versions
L Plum, M Schubert, JC Brüning - Trends in Endocrinology & Metabolism, 2005 - Elsevier The insulin receptor (IR) is expressed in various regions of the developing and adult brain, and
its functions have become the focus of recent research. Insulin enters the central nervous system
(CNS) through the blood–brain barrier by receptor-mediated transport to regulate food ... Cited by 103 - Related articles - All 3 versions
EP Haber, HMA Ximenes, J Procopio, … - Journal of cellular …, 2003 - interscience.wiley.com Hyperlipidemia is frequently associated with insulin resistance states as found in type 2 diabetes
and obesity. Effects of free fatty acids (FFA) on pancreatic -cells have long been recognized.
Acute exposure of the pancreatic -cell to FFA results in an increase of insulin release, ... Cited by 75 - Related articles - BL Direct - All 4 versions
I Franklin, J Gromada, A Gjinovci, S Theander, CB … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During hyperglycemia, glucagon
secretion is inhibited by paracrine factors from other islet cells, but in type 1 and type 2 diabetic
patients, this suppression is lost. We investigated the effects of β-cell secretory products ... Cited by 74 - Related articles - All 4 versions
JD Johnson, S Misler - Proceedings of the National Academy of …, 2002 - National Acad Sciences Recent studies suggest a role for autocrine insulin signaling in beta cells, but the mechanism
and function of insulin-stimulated Ca 2+ signals is uncharacterized. We examined Ca 2+ -dependent
insulin signaling in human beta cells. Two hundred nanomolar insulin elevated [Ca 2+ ] c ... Cited by 74 - Related articles - BL Direct - All 11 versions
IB Leibiger, B Leibiger, PO Berggren - FEBS letters, 2002 - Elsevier Pancreatic β-cell function is essential for the regulation of glucose homeostasis and its impairment
leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from neural and
humoral components and intraislet cell–cell communication act together to guarantee an ... Cited by 65 - Related articles - All 6 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
R Kulkarni - Biochemical Society Transactions, 2002 - bst.portlandpress.com The insulin/insulin-like growth factor-1 (IGF-1) signalling pathways are present in most mammalian
cells and play important roles in the growth and metabolism of tissues. Most proteins in these
pathways have also been identified in the b-cells of the pancreatic islets. Tissue-specific ... Cited by 56 - Related articles - Cached - BL Direct - All 11 versions
- ►nih.gov M Zhang, P Goforth, R Bertram, A Sherman, L Satin - Biophysical journal, 2003 - Elsevier [Ca 2+ ] i and electrical activity were compared in isolated β-cells and islets using standard
techniques. In islets, raising glucose caused a decrease in [Ca 2+ ] i followed by a plateau and
then fast (2–3 min −1 ), slow (0.2–0.8 min −1 ), or a mixture of fast and slow [Ca 2+ ] i ... Cited by 51 - Related articles - BL Direct - All 12 versions
- ►nih.gov L Plum, X Ma, B Hampel, N Balthasar, R … - Journal of Clinical …, 2006 - Am Soc Clin Investig 1 Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne
and Center of Molecular Medicine Cologne (CMMC), Cologne, Germany. 2 Klinik II und Poliklinik
für Innere Medizin, University of Cologne and CMMC, Cologne, Germany. 3 University ... Cited by 52 - Related articles - BL Direct - All 16 versions
