BJ Pettus, CE Chalfant, YA Hannun - BBA-Molecular and Cell Biology of Lipids, 2002 - Elsevier Although the first sphingolipids were isolated and characterized in the late
1800s, they have been long regarded as structural and inert components of cell
membranes. Ceramide itself is a membrane sphingolipid comprised of an ... Cited by 339 - Related articles - All 6 versions
WJ van Blitterswijk, AH van der Luit, RJ … - Biochemical Journal, 2003 - pubmedcentral.nih.gov The physiological role of ceramide formation in response to cell stimulation
remains controversial. Here, we emphasize that ceramide is not a priori an
apoptotic signalling molecule. Recent work points out that the conversion ... Cited by 204 - Related articles - BL Direct - All 5 versions
- ►jbc.org JA Chavez, TA Knotts, LP Wang, G Li, RT … - Journal of Biological Chemistry, 2003 - ASBMB Multiple studies suggest that lipid oversupply to skeletal muscle contributes to
the development of insulin resistance, perhaps by promoting the accumulation of
lipid metabolites capable of inhibiting signal transduction. Herein we ... Cited by 156 - Related articles - BL Direct - All 5 versions
MM Hill, BA Hemmings - Pharmacology and Therapeutics, 2002 - Elsevier Protein kinase B (PKB, also called Akt) is an important regulator of cell
proliferation and survival. Amplification of genes encoding PKB isoforms has
been found in several types of human cancers. In addition, mutations in the ... Cited by 144 - Related articles - All 8 versions
CE Wrede, LM Dickson, MK Lingohr, I Briaud … - Journal of Biological Chemistry, 2002 - ASBMB Free fatty acids (FFA) have been reported to reduce pancreatic -cell mitogenesis
and to increase apoptosis. Here we show that the FFA, oleic acid, increased
apoptosis 16-fold in the pancreatic -cell line, INS-1, over a 18-h period ... Cited by 127 - Related articles - BL Direct - All 6 versions
- ►jbc.org Y Tanaka, MV Gavrielides, Y Mitsuuchi, T … - Journal of Biological Chemistry, 2003 - ASBMB Activation of protein kinase C (PKC) by phorbol esters or diacylglycerol
mimetics induces apoptosis in androgen-dependent prostate cancer cells, an
effect that involves both the activation of the classic PKC and the novel ... Cited by 129 - Related articles - BL Direct - All 4 versions
- ►202.201.6.125 [PDF] WA Teft, MG Kirchhof, J Madrenas, 2006 - Annual Reviews Abstract Within the paradigm of the two-signal model of lymphocyte activation,
the interest in costimulation has witnessed a remarkable emergence in the past
few years with the discovery of a large array of molecules that can serve ... Cited by 126 - Related articles - BL Direct - All 6 versions
BD Hegarty, SM Furler, J Ye, GJ Cooney, EW … - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 120 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in
insulin resistance, but the precise nature of the lipid species that produce
insulin resistance in human muscle are unknown. Ceramides, either generated ... Cited by 117 - Related articles - BL Direct - All 9 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
