- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to
pancreatic β cells, causing impaired insulin secretion. IL-1β is a
proinflammatory cytokine acting during the autoimmune process of type 1 ... Cited by 324 - Related articles - BL Direct - All 7 versions
A Kumar, Y Takada, AM Boriek, BB Aggarwal - Journal of molecular medicine, 2004 - Springer Page 1. J Mol Med (2004) 82:434–448 DOI 10.1007/s00109-004-0555-y REVIEW Ashok
Kumar · Yasunari Takada · Aladin M. Boriek · Bharat B. Aggarwal ... Cited by 240 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 171 - Related articles - BL Direct - All 10 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes
mellitus (T1DM) and T2DM. In T1DM, cytokines contribute to ß-cell destruction
through nuclear factor- B (NF- B) activation. Previous studies suggested ... Cited by 134 - Related articles - BL Direct - All 3 versions
- ►physiology.org DD Bannerman, SE Goldblum - American Journal of Physiology- Lung Cellular and …, 2003 - Am Physiological Soc Gram-negative bacterial sepsis remains a common, life-threatening event. The
prognosis for patients who develop sepsis-related complications, including the
development of acute respiratory distress syndrome (ARDS), remains poor. A ... Cited by 130 - Related articles - BL Direct - All 11 versions
- ►shouxi.net AK Cardozo, F Ortis, J Storling, YM Feng, J … - Diabetes, 2005 - Am Diabetes Assoc Cytokines and free radicals are mediators of β-cell death in type 1 diabetes.
Under in vitro conditions, interleukin-1β (IL-1β) + γ-interferon (IFN-γ)
induce nitric oxide (NO) production and apoptosis in rodent and human ... Cited by 102 - Related articles - All 8 versions
- ►daegu.ac.kr [PDF] B Kutlu, AK Cardozo, MI Darville, M Kruhoffer, … - DIABETES-NEW YORK-, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in
type 1 diabetes. In vitro exposure of insulin-producing INS-1E cells to the
cytokines inter- leukin (IL)-1 interferon (IFN)- leads to a signifi- cant ... Cited by 91 - Related articles - BL Direct - All 7 versions
- ►endojournals.org E Zeender, K Maedler, D Bosco, T Berney, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Decreased functional ß-cell mass in type 1 and type 2 diabetes is due to
ß-cell apoptosis and impaired secretory function suggested to be mediated, in
part, by immune- and/or high-glucose-induced production of IL-1ß acting ... Cited by 74 - Related articles - BL Direct - All 4 versions
