SH Yang, AD Sharrocks, AJ Whitmarsh - Gene, 2003 - Elsevier A major function of the mitogen-activated protein kinase (MAPK) pathways is to control eukaryotic
gene expression programmes in response to extracellular signals. MAPKs directly control gene
expression by phosphorylating transcription factors. However, it is becoming clear that ... Cited by 215 - Related articles - All 6 versions
- ►nih.gov JD Johnson, NT Ahmed, DS Luciani, Z Han … - Journal of Clinical …, 2003 - Am Soc Clin Investig Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose
tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from
the perfused pancreas. Surprisingly, insulin secretion in perifusion or static incubation ... Cited by 151 - Related articles - BL Direct - All 8 versions
H Kaneto, G Xu, N Fujii, S Kim, S Bonner-Weir, GC … - Journal of Biological …, 2002 - ASBMB Oxidative stress, which is found in pancreatic β-cells in the diabetic state, suppresses insulin
gene transcription and secretion, but the signaling pathways involved in the β-cell dysfunction
induced by oxidative stress remain unknown. In this study, subjecting rat islets to ... Cited by 133 - Related articles - BL Direct - All 4 versions
- ►physiology.org A Lechner, JF Habener - American Journal of Physiology- …, 2003 - Am Physiological Soc In view of the recent success in pancreatic islet transplantation, interest in treating diabetes by
the delivery of insulin-producing -cells has been renewed. Because differentiated pancreatic
-cells cannot be expanded significantly in vitro, -cell stem or progenitor cells are seen as ... Cited by 99 - Related articles - BL Direct - All 3 versions
D Kawamori, Y Kajimoto, H Kaneto, Y Umayahara, Y … - Diabetes, 2003 - Am Diabetes Assoc Oxidative stress is induced in pancreatic β-cells under diabetic conditions and causes β-cell
dysfunction. Antioxidant treatment of diabetic animals leads to recovery of insulin biosynthesis
and increases the expression of its controlling transcription factor, pancreatic duodenal ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org [PDF] K Piper, S Brickwood, LW Turnpenny, IT … - Journal of …, 2004 - Soc Endocrinology Understanding gene expression profiles during early human pancreas development is limited
by comparison to studies in rodents. In this study, from the inception of pancreatic formation,
embryonic pancreatic epithelial cells, approximately half of which were proliferative, ... Cited by 62 - Related articles - BL Direct - All 6 versions
DK Hagman, LB Hays, SD Parazzoli, V Poitout - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to both defective
insulin secretion from the pancreatic beta cell and peripheral insulin resistance in type 2
diabetes. Previously, we have shown that prolonged exposure of isolated rat islets of ... Cited by 42 - Related articles - BL Direct - All 10 versions
AL Mosley, JA Corbett, S Ozcan - Molecular Endocrinology, 2004 - Endocrine Soc Regulation of insulin gene expression in response to increases in blood glucose levels is essential
for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose
stimulates insulin gene transcription are not known. We have shown previously that ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►jbc.org D Kawamori, H Kaneto, Y Nakatani, T Matsuoka, M … - Journal of Biological …, 2006 - ASBMB It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway
induce the nucleocytoplasmic translocation of the pancreatic transcription factor PDX-1, which
leads to pancreatic -cell dysfunction. In this study, we have shown that the forkhead ... Cited by 43 - Related articles - BL Direct - All 8 versions
S Ashizawa, FC Brunicardi, XP Wang - Pancreas, 2004 - journals.lww.com Many transcription factors are critical for ensuring proper embryonic development of the endocrine
pancreas and normal islet function. The transcription factor pancreatic duodenal homeobox 1
(PDX-1) is uniformly expressed in early pancreatic buds of embryos as well as the β and ... Cited by 39 - Related articles - BL Direct - All 2 versions
