- ►nutrition.org P Cohen, JM Friedman - Journal of Nutrition, 2004 - Am Soc Nutrition The incidence of obesity has increased sharply in recent years, making it one of
the most urgent public health concerns worldwide. The hormone leptin is the
central mediator in a negative feedback loop regulating energy homeostasis. ... Cited by 74 - Related articles - All 3 versions
A Ahluwalia, KH Clodfelter, DJ Waxman - Molecular Endocrinology, 2004 - Endocrine Soc GH has diverse physiological actions and regulates the tissue-specific
expression of numerous genes involved in growth, metabolism, and
differentiation. Several of the effects of GH on somatic growth and gene ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org V Simha, LS Szczepaniak, AJ Wagner, AM … - Diabetes Care, 2003 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We examined the effects 8–10 months of
subcutaneous leptin replacement therapy on insulin sensitivity, IMCL, and
intrahepatic lipid content in two patients with acquired generalized ... Cited by 67 - Related articles - BL Direct - All 7 versions
S Kim, I Sohn, JI Ahn, KH Lee, YS Lee, YS … - Gene, 2004 - Elsevier To understand the molecular mechanisms underlying alterations in the
pathophysiologic status of dietary obesity, we examined hepatic genes
differentially expressed in a long-term high-fat intake-induced obesity ... Cited by 54 - Related articles - All 5 versions
M Ohsugi, C Cras-Meneur, Y Zhou, E Bernal- … - Journal of Biological Chemistry, 2005 - ASBMB Running Title: Multiple roles of insulin signaling in islet cells ... Reduced
Expression of the Insulin Receptor in Mouse Insulinoma (MIN6) Cells Reveals
Multiple Roles of Insulin Signaling in Gene Expression, Proliferation, ... Cited by 37 - Related articles - All 5 versions
- ►diabetesjournals.org M Ohsugi, C Cras-Méneur, Y Zhou, W Warren, … - Diabetes, 2004 - Am Diabetes Assoc Glucose and insulin are important regulators of islet ß-cell growth and
function by activating signaling pathways resulting in transcriptional changes
that lead to adaptive responses. Several immediate early genes have been ... Cited by 32 - Related articles - BL Direct - All 4 versions
MW Bradbury, PD Berk - Clinics in Liver Disease, 2004 - Elsevier Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)
are conditions in which an excess of lipid, principally triglycerides (TGs),
accumulates in hepatocytes. In early NAFLD, simple hepatocellular steatosis ... Cited by 29 - Related articles - BL Direct - All 2 versions
- ►daegu.ac.kr [PDF] T Takamura, M Sakurai, T Ota, H Ando, M … - Diabetologia, 2004 - Springer Aims/hypothesis. Type 2 diabetes is characterised by excessive hepatic glucose
production and frequently leads to systemic vascular complications. We there-
fore analysed the relationship between the gene ex- pression profile in the ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►nih.gov BN Reid, GP Ables, OA Otlivanchik, G … - Journal of Biological Chemistry, 2008 - ASBMB Hepatic steatosis is often associated with insulin resistance and obesity and
can lead to steatohepatitis and cirrhosis. In this study, we have demonstrated
that hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), ... Cited by 18 - Related articles - All 5 versions
CE Dohrmann - Drug discovery today, 2004 - Elsevier The prevalence of metabolic diseases is taking on epidemic proportions and poses
a serious threat to human health. Current treatment options have proven
insufficient to cope with obesity and diabetes because they rarely restore ... Cited by 14 - Related articles - All 4 versions
