- ►physiology.org IC Mcmillen, JS Robinson - Physiological reviews, 2005 - Am Physiological Soc The "fetal" or "early" origins of adult disease hypothesis was originally put
forward by David Barker and colleagues and stated that environmental factors,
particularly nutrition, act in early life to program the risks for adverse ... Cited by 434 - Related articles - All 11 versions
- ►nih.gov RS Garofalo, SJ Orena, K Rafidi, AJ Torchia, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell
growth, survival, and metabolism. It remains unclear, however, whether the
functions of individual Akt/PKB isoforms are distinct. To investigate the ... Cited by 196 - Related articles - BL Direct - All 10 versions
- ►reproduction-online.org AL Fowden, AJ Forhead - Reproduction, 2004 - Soc Reprod Fertility Epidemiological findings and experimental studies in animals have shown that
individual tissues and whole organ systems can be programmed in utero during
critical periods of development with adverse consequences for their ... Cited by 124 - Related articles - BL Direct - All 3 versions
- ►physiology.org L Bouwens, I Rooman - Physiological reviews, 2005 - Am Physiological Soc Beta-cell mass regulation represents a critical issue for understanding
diabetes, a disease characterized by a near-absolute (type 1) or relative (type
2) deficiency in the number of pancreatic beta cells. The number of islet ... Cited by 115 - Related articles - BL Direct - All 6 versions
CN Hales, SE Ozanne - The Journal of Physiology, 2003 - Physiological Soc Many epidemiological studies have now shown a strongly increased risk of
developing type 2 diabetes and the metabolic syndrome in adults who as neonates
showed signs of poor early (fetal and early postnatal) growth. The thrifty ... Cited by 110 - Related articles - BL Direct - All 7 versions
- ►physiology.org TD Pham, NK MacLennan, CT Chiu, GS … - … Journal of Physiology- Regulatory, Integrative and …, 2003 - Am Physiological Soc Uteroplacental insufficiency causes intrauterine growth retardation (IUGR),
which is associated with adult onset diseases such as hypertension. Previous
studies demonstrate that growth retardation in humans and rats decreases ... Cited by 104 - Related articles - BL Direct - All 4 versions
KK Ong, DB Dunger - European Journal of Endocrinology, 2004 - eje.org Size at birth and early postnatal growth rates are important determinants of
human perinatal survi- val; they also predict the tempo of growth, adult height
and long-term risks for obesity, type 2 diabetes and cardiovascular ... Cited by 95 - Related articles - View as HTML - BL Direct - All 11 versions
- ►ucilmsa.org [PDF] DS Fernandez-Twinn, SE Ozanne - Physiology & behavior, 2006 - Elsevier Fetal programming is gaining momentum as a highly documented phenomenon which
links poor early growth to adult disease. It is backed up by large cohorts in
epidemiological studies worldwide and has been tested in various animal ... Cited by 76 - Related articles - All 5 versions
- ►diabetesjournals.org J Boloker, SJ Gertz, RA Simmons - Diabetes, 2002 - Am Diabetes Assoc We have developed a model of gestational diabetes in the rat to determine
whether an altered metabolic intrauterine milieu is directly linked to the
development of diabetes later in life. Uteroplacental insufficiency is ... Cited by 70 - Related articles - BL Direct - All 4 versions
E Zambrano, PM Martinez-Samayoa, CJ … - The Journal of physiology, 2005 - Physiological Soc Compelling epidemiological and experimental evidence indicates that a suboptimal
environment during fetal and neonatal development in both humans and animals may
programme offspring susceptibility to later development of several chronic ... Cited by 67 - Related articles - All 9 versions
