- ►itmhrt.ca [PDF] C Esau, S Davis, SF Murray, XX Yu, SK … - Cell metabolism, 2006 - Elsevier Current understanding of microRNA (miRNA) biology is limited, and antisense
oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their
functionalization. To uncover the role of the liver-specific miR-122 in the ... Cited by 237 - Related articles - All 14 versions
- ►sciencesignaling.org [PDF] J Grimsby, R Sarabu, WL Corbett, NE Haynes, … - Science, 2003 - sciencemag.org Page 1. DOI: 10.1126/science.1084073 , 370 (2003); 301 Science et al. Joseph Grimsby,
in Diabetes Therapy Allosteric Activators of Glucokinase: Potential Role ... Cited by 187 - Related articles - All 12 versions
- ►jbc.org K Oishi, K Miyazaki, K Kadota, R Kikuno, T … - Journal of Biological Chemistry, 2003 - ASBMB CLOCK is a positive component of a transcription/translation-based negative
feedback loop of the central circadian oscillator in the suprachiasmatic nucleus
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AL Gloyn - Human mutation, 2003 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a
crucial role in the regulation of insulin secretion and has been termed the
pancreatic beta-cell sensor. Given its central role in the regulation of ... Cited by 121 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and
catalyzes the rate-limiting step for β-cell glucose metabolism. We report two
novel GCK mutations (T65I and W99R) that have arisen de novo in two ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►ox.ac.uk [PDF] KJ Brocklehurst, VA Payne, RA Davies, D … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) has a major role in the control of blood glucose homeostasis
and is a strong potential target for the pharmacological treatment of type 2
diabetes. We report here the mechanism of action of two novel and potent ... Cited by 75 - Related articles - BL Direct - All 6 versions
XX Yu, SF Murray, SK Pandey, SL Booten, D … - Hepatology, 2005 - interscience.wiley.com In this study, we investigated the role of acyl-coenzyme A:diacylglycerol
acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by
reducing its expression in liver and fat with an optimized antisense ... Cited by 73 - Related articles - BL Direct - All 3 versions
RM Crooke, MJ Graham, KM Lemonidis, CP … - The Journal of Lipid Research, 2005 - ASBMB High levels of plasma apolipoprotein B-100 (apoB-100), the principal
apolipoprotein of LDL, are associated with cardiovascular disease. We
hypothesized that suppression of apoB-100 mRNA by an antisense ... Cited by 72 - Related articles - All 4 versions
- ►jlr.org MJ Graham, KM Lemonidis, CP Whipple, A … - The Journal of Lipid Research, 2007 - ASBMB Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of
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pleiotropic cellular responses. We have characterized the effect of recombinant
IGF proteins, as well as third-generation adenoviral vectors encoding ... Cited by 29 - Related articles - BL Direct - All 4 versions
