JW Goding, B Grobben, H Slegers - BBA-Molecular Basis of Disease, 2003 - Elsevier The ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) multigene family
contains five members. NPP1-3 are type II transmembrane metalloenzymes
characterized by a similar modular structure composed of a short ... Cited by 100 - Related articles - All 4 versions
- ►endojournals.org M Li, JF Youngren, A Dunaif, ID Goldfine, … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Insulin resistance is characteristic of many patients with polycystic ovary
syndrome (PCOS). Several studies have suggested that a decrease in insulin
receptor (IR) autophosphorylation is a significant component of this ... Cited by 69 - Related articles - BL Direct - All 6 versions
S Li, ND Covino, EG Stein, JH Till, SR … - Journal of Biological Chemistry, 2003 - ASBMB Tyrosine 984 in the juxtamembrane region of the insulin receptor, between the
transmembrane helix and the cytoplasmic tyrosine kinase domain, is conserved
among all insulin receptor-like proteins from hydra to humans. ... Cited by 16 - Related articles - BL Direct - All 9 versions
C Pender, ID Goldfine, VP Manchem, JL Evans … - Journal of Biological Chemistry, 2002 - ASBMB In type 2 diabetes mellitus, impaired insulin signaling leads to hyperglycemia
and other metabolic abnormalities. TLK19780, a non-peptide small molecule, is a
new member of a novel class of anti-diabetic agents that function as ... Cited by 14 - Related articles - BL Direct - All 4 versions
H Dong, BA Maddux, J Altomonte, M Meseck, D … - Diabetes, 2005 - Am Diabetes Assoc The ectoenzyme, plasma cell membrane glycoprotein-1 (PC-1), is an insulin
receptor (IR) inhibitor that is elevated in cells and tissues of
insulin-resistant humans. However, the effects of PC-1 overexpression on ... Cited by 8 - Related articles - All 5 versions
JR Petrie, CG Perry - emd, 2002 - Informa Pharma Science The global prevalence of Type 2 diabetes mellitus is increasing rapidly, at
least in part as a function of obesity. The results of the United Kingdom
Prospective Diabetes Study emphasise the importance of developing safe, ... Cited by 8 - Related articles - All 4 versions
- ►aspetjournals.org RA Velliquette, JE Friedman, J Shao, BB … - Journal of Pharmacology and Experimental …, 2005 - ASPET Insulin resistance clusters with hyperlipidemia, impaired glucose tolerance, and
hypertension as metabolic syndrome X. We tested a low molecular weight insulin
receptor activator, demethylasterriquinone B-1 (DMAQ-B1), and a novel ... Cited by 7 - Related articles - BL Direct - All 5 versions
PM Fischer - Drug Design Reviews-Online, 2005 - ingentaconnect.com 1. INTRODUCTION The majority of molecular targets that are currently being
pursued for the purposes of small molecule drug discovery are enzymes and cell
surface receptors, a particularly those that naturally bind small ligands, ... Cited by 6 - Related articles
M Cheng, S Chen, SR Schow, VP Manchem, WR … - Journal of cellular biochemistry, 2004 - interscience.wiley.com Protease inhibitor (PI) therapy for the treatment of patients infected with
human immunodeficiency virus is frequently associated with insulin resistance
and diabetic complications. These adverse effects of PI treatment result to ... Cited by 5 - Related articles - BL Direct - All 4 versions
BJ Clodfelder, BM Gullick, HC Lukaski, Y … - Journal of Biological Inorganic Chemistry, 2005 - Springer Abstract The in vivo effects of gavage administration of the synthetic,
functional biomimetic cation [Cr 3 O(O 2 CCH 2 CH 3 ) 6 (H 2 O) 3 ] + to healthy
and type 2 diabetic model rats are described. After 24 weeks of treatment ... Cited by 4 - Related articles - All 2 versions
