- ►diabetesjournals.org PE Cryer, SN Davis, H Shamoon - Diabetes Care, 2003 - Am Diabetes Assoc Iatrogenic hypoglycemia causes recurrent morbidity in most people with type 1 diabetes and
many with type 2 diabetes, and it is sometimes fatal. The barrier of hypoglycemia generally precludes
maintenance of euglycemia over a lifetime of diabetes and thus precludes full realization ... Cited by 373 - Related articles - All 8 versions
- ►shouxi.net PE Cryer - New England Journal of Medicine, 2004 - content.nejm.org In this article, I discuss the clinical problem of hypoglycemia in diabetes from the perspective
of pathophysiology. First, the syndromes of defective glucose counterregulation and hypoglycemia
without warning symptoms (known as "hypoglycemia unawareness") are described, ... Cited by 156 - Related articles - BL Direct - All 6 versions
- ►nih.gov D Teves, TO Videen, PE Cryer, WJ … - Proceedings of the …, 2004 - National Acad Sciences Studies in humans implicate the medial prefrontal cortex (MPFC) in complex cognitive and emotional
states. We measured regional cerebral blood flow (CBF) four times each during euglycemia
(5.2 ± 0.2 mmol/liter) and hypoglycemia (3.0 ± 0.3 mmol/liter) in nine normal human ... Cited by 45 - Related articles - BL Direct - All 8 versions
RE Warren, BM Frier - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com Acute hypoglycaemia impairs cerebral function, and available data indicate that cognitive performance
becomes impaired at a blood glucose level of 2.6–3.0 mmol/l in healthy subjects. Methodological
problems limit comparisons between studies, but in general complex tasks are more ... Cited by 27 - Related articles - BL Direct - All 4 versions
D Smith, S Amiel - Diabetologia, 2002 - Springer The intention of this paper is to critically review the current state of knowledge of the role of the
brain in the syndrome of hypoglycaemia unawareness. Both the role of the brain in the detection
of hypo- glycaemia and initiation of the counterregulatory re- sponses and the function of ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►sinica.edu.tw [PDF] JP Blass - Glucose metabolism in the brain, 2002 - books.google.com 326 JOHN P. BLASS C. Cerebrovascular Disease D. Aging IX. Summary and Conclusions References
I. Introduction A. HISTORICAL ASPECTS A relationship between impairments of glucose oxidation
and deficien- cies in neurological function was recognized even before the major metabo- ... Cited by 19 - Related articles - BL Direct - All 4 versions
EC McNay, RS Sherwin - Diabetes, 2004 - Am Diabetes Assoc The effects of recurrent hypoglycemia (RH) on cognition in human subjects remain
controversial, perhaps in part due to difficulty in completely controlling previous hypoglycemic
history. We used a model of RH in nondiabetic and diabetic rats to examine the effects of ... Cited by 19 - Related articles - BL Direct - All 5 versions
EM Bingham, JT Dunn, D Smith, J Sutcliffe-Goulden, LJ … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Hypoglycaemia unawareness in type 1 diabetes increases the risk
of severe hypogly- caemia and impairs quality of life for people with diabetes. To explore the
central mechanisms of hypoglycaemia awareness, we used [ 11 C]-3-O-methyl- D ... Cited by 13 - Related articles - BL Direct - All 3 versions
JW Mastaitis, E Wurmbach, H Cheng, SC Sealfon, CV … - Diabetes, 2005 - Am Diabetes Assoc The robust neuroendocrine counterregulatory responses induced by hypoglycemia protect the
brain by restoring plasma glucose, but little is known about molecular responses to hypoglycemia
that may also be neuroprotective. To clarify these mechanisms, we examined gene ... Cited by 13 - Related articles - All 5 versions
- ►shouxi.net JT Dunn, I Cranston, PK Marsden, SA Amiel, LJ Reed - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Epinephrine responses to hypoglycemia were reduced in hypoglycemia unawareness
(P < 0.0003), as were symptoms. Statistical parametric mapping (SPM) of FDG uptake using
SPM2 at a statistical threshold of P < 0.005 showed increased FDG uptake in left ... Cited by 10 - Related articles - BL Direct - All 4 versions
