- ►nih.gov RJ Steptoe, JM Ritchie, LC Harrison - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Bone marrow or hematopoietic stem cell transplantation is a potential treatment
for autoimmune disease. The clinical application of this approach is, however,
limited by the risks associated with allogeneic transplantation. In ... Cited by 61 - Related articles - BL Direct - All 8 versions
- ►rupress.org E Jaeckel, L Klein, N Martin-Orozco, H von … - Journal of Experimental Medicine, 2003 - jem.rupress.org Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic
acid decarboxylase (GAD) in ß cells have suggested that GAD represents an
autoantigen essential for initiating and maintaining the diabetogenic ... Cited by 49 - Related articles - All 7 versions
- ►diabetesjournals.org W Karges, K Pechhold, S Al Dahouk, I … - Diabetes, 2002 - Am Diabetes Assoc Insulin has been used to modify T-cell autoimmunity in experimental models of
type 1 diabetes. In a large clinical trial, the effect of insulin to prevent
type 1 diabetes is currently investigated. We here show that insulin can ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Peppa, C He, M Hattori, R McEvoy, F Zheng … - Diabetes, 2003 - Am Diabetes Assoc Advanced glycation end products (AGEs) are implicated in β-cell oxidant stress.
Diet-derived AGE (dAGE) are shown to contribute to end-organ toxicity attributed
to diabetes. To assess the role of dAGE on type 1 diabetes, NOD mice were ... Cited by 34 - Related articles - BL Direct - All 5 versions
JP Palmer, GA Fleming, CJ Greenbaum, KC … - Diabetes, 2004 - Am Diabetes Assoc The underlying cause of type 1 diabetes, loss of β-cell function, has become
the therapeutic target for a number of interventions in patients with type 1
diabetes. Even though insulin therapies continue to improve, it remains ... Cited by 27 - Related articles - All 2 versions
- ►jimmunol.org P Halbout, JP Briand, C Becourt, S Muller, C … - The Journal of Immunology, 2002 - Am Assoc Immnol Immunization against insulin, insulin B chain, or B chain peptide B 9–23
(preproinsulin peptide II 33–47 ) prevents diabetes in the nonobese diabetic
(NOD) mouse. Whether or not peptide II 33–47 is the only proinsulin ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org RJ Steptoe, JM Ritchie, LK Jones, LC … - Diabetes, 2005 - Am Diabetes Assoc The nature of the T-cell response to antigen is governed by the activation state
of the antigen-presenting dendritic cell (DC). Immature or resting DCs have been
shown to induce T-cell responses that may protect against the development ... Cited by 25 - Related articles - All 5 versions
- ►jimmunol.org AL Every, DR Kramer, SI Mannering, AM Lew, … - The Journal of Immunology, 2006 - Am Assoc Immnol Insulin, an autoantigen in type 1 diabetes, when administered mucosally to
diabetes-prone NOD mice induces regulatory T cells (T reg ) that protect against
diabetes. Compared with protein, Ag encoded as DNA has potential advantages ... Cited by 24 - Related articles - All 4 versions
I Jaakkola, S Jalkanen, A Hanninen - European journal of immunology, 2003 - interscience.wiley.com Activation of an islet-specific immune response is an early yet essential step
in autoimmune diabetes. The immune cells and antigen(s) involved in this early
step and its anatomical site remain incompletely understood. To directly ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org AP Olcott, J Tian, V Walker, H Dang, B … - The Journal of Immunology, 2005 - Am Assoc Immnol As organ-specific autoimmune diseases do not become manifest until
well-advanced, interventive therapies must inhibit late-stage disease processes.
Using a panel of immunogenic peptides from various cell Ags, we evaluated ... Cited by 15 - Related articles - BL Direct - All 5 versions
