DT Odom, N Zizlsperger, DB Gordon, GW Bell, … - Science, 2004 - sciencemag.org The transcriptional regulatory networks that specify and maintain human tissue
diversity are largely uncharted. To gain insight into this circuitry, we used
chromatin immunoprecipitation combined with promoter microarrays to ... Cited by 577 - Related articles - All 7 versions
- ►ucsf.edu [PDF] ME Wilson, D Scheel, MS German - Mechanisms of development, 2003 - Elsevier The specialized endocrine and exocrine cells of the pancreas originally derive
from a pool of apparently identical cells in the early gut endoderm. Serial
changes in their gene expression program, controlled by a hierarchy of ... Cited by 189 - Related articles - All 8 versions
- ►genopole.fr [PDF] LC Murtaugh, DA Melton - Annual review of cell and developmental biology, 2003 - Annual Reviews ▪ Abstract Type I diabetes results from the autoimmune-mediated destruction of
pancreatic beta (β) cells, which regulate blood sugar levels by secretion of
insulin. Recent clinical data suggest that the disease could be cured if an ... Cited by 118 - Related articles - BL Direct - All 6 versions
JM Servitja, J Ferrer - Diabetologia, 2004 - Springer Transcription factors provide the genetic instructions that drive pancreatic
development and enable mature beta cells to function properly. To understand
fully how this is accomplished, it is necessary to unravel the regulatory ... Cited by 107 - Related articles - BL Direct - All 4 versions
D Jung, GA Kullak-Ublick - Hepatology, 2003 - interscience.wiley.com Bile acids regulate the expression of genes involved in cholesterol homeostasis.
They are ligands of the farnesoid X receptor, which induces small heterodimer
partner (SHP)-1, a transcriptional repressor of bile acid synthetic ... Cited by 97 - Related articles - BL Direct - All 4 versions
- ►jbc.org K Gerrish, MA Cissell, R Stein - Journal of Biological Chemistry, 2001 - ASBMB The PDX-1 homeodomain transcription factor regulates pancreatic development and
adult islet cell function. Expression of the pdx-1 gene is almost exclusively
localized to cells within the adult endocrine pancreas. Islet ... Cited by 83 - Related articles - BL Direct - All 3 versions
- ►endojournals.org T Vilsboll, FK Knop, T Krarup, A Johansen, S … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc The effect of the insulinotropic incretin hormone, glucagon-like peptide-1
(GLP-1), is preserved in typical middle-aged, obese, insulin-resistant type 2
diabetic patients, whereas a defective amplification of the so-called ... Cited by 77 - Related articles - BL Direct - All 4 versions
- ►nih.gov RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in
maturity-onset diabetes of the young (MODY). To determine the contribution of
HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, ... Cited by 75 - Related articles - All 7 versions
- ►nih.gov SK Hansen, M Párrizas, ML Jensen, S Pruhova … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and
HNF-1α impair insulin secretion and cause maturity onset diabetes of the young
(MODY). HNF-4α is known to be an essential positive regulator of HNF-1α. ... Cited by 71 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5%
of the population in Western societies and over 150 million people worldwide. It
is characterized by elevation of the blood glucose concentration, usually ... Cited by 70 - Related articles - All 5 versions
