- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP) exert important effects on β-cells to stimulate glucose-dependent insulin secretion. Both
peptides also regulate β-cell proliferation and cytoprotection. GLP-1, but not GIP, inhibits ... Cited by 284 - Related articles - All 13 versions
- ►physiology.org JJ Holst, J Gromada - American Journal of Physiology- …, 2004 - Am Physiological Soc The available evidence suggests that about two-thirds of the insulin response to an oral glucose
load is due to the potentiating effect of gut-derived incretin hormones. The strongest candidates
for the incretin effect are glucose-dependent insulinotropic polypeptide (GIP) and ... Cited by 180 - Related articles - BL Direct - All 4 versions
- ►ohsu.edu [PDF] J Tuomilehto, G Hu, S Bidel, J Lindstrom, P Jousilahti - Jama, 2004 - Am Med Assoc You are seeing this message because your Web browser does not support basic Web
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your experience on this site better. ... Context Only a few studies of coffee consumption ... Cited by 154 - Related articles - BL Direct - All 9 versions
T Vilsbøll, JJ Holst - Diabetologia, 2004 - Springer When glucose is taken orally, insulin secretion is stim- ulated much more than it is when glucose
is infused intravenously so as to result in similar glucose con- centrations. This effect, which is
called the incretin ef- fect and is estimated to be responsible for 50 to 70% of the insulin ... Cited by 145 - Related articles - BL Direct - All 7 versions
- ►aspetjournals.org KE Mayo, LJ Miller, D Bataille, S Dalle, B Goke, B … - Pharmacological reviews, 2003 - ASPET Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of the
pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and subserve
multiple biological functions, including regulation of growth, nutrient intake, and transit ... Cited by 143 - Related articles - BL Direct - All 7 versions
T Vilsbøll, T Krarup, S Madsbad, J Holst - Diabetologia, 2002 - Springer Aims/hypothesis. Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type
II (non- insulin-dependent) diabetes mellitus, whereas glu- cose-dependent insulinotropic polypeptide
(GIP) is less effective. Our investigation evaluated “early” (protocol 1) – and “late phase” ( ... Cited by 135 - Related articles - BL Direct - All 4 versions
JJ Meier, MA Nauck, WE Schmidt, B Gallwitz - Regulatory peptides, 2002 - Elsevier After the ingestion of fat- and glucose-rich meals, gut hormones are secreted into the circulation
in order to stimulate insulin secretion. This so-called “incretin effect” is primarily conferred by
Glucagon-like peptide 1 (GLP-1) and Gastric Inhibitory Polypeptide (GIP). In contrast to ... Cited by 124 - Related articles - All 5 versions
- ►endojournals.org JJ Meier, B Gallwitz, S Salmen, O Goetze, JJ … - Journal of Clinical …, 2003 - Endocrine Soc The effects of different iv doses of glucagon-like peptide 1 (GLP-1) on glucose homeostasis and
gastric emptying were compared in patients with type 2 diabetes. Twelve patients with type 2
diabetes received three different infusion rates of GLP-1 (0.4, 0.8, and 1.2 pmol/kg·min) or ... Cited by 122 - Related articles - BL Direct - All 5 versions
DJ Drucker - eid, 2003 - informahealthcare.com Incretins are peptide hormones, exemplified by glucose-dependent insulino- tropic peptide and
glucagon-like peptide 1 that are released from the gut in response to nutrient ingestion and enhance
glucose-stimulated insulin secre- tion. Incretin action is terminated due to N-terminal ... Cited by 118 - Related articles - All 6 versions
MA Nauck, JJ Meier - Regulatory peptides, 2005 - Elsevier Glucagon-like peptide 1 (GLP-1) was discovered as an insulinotropic gut hormone, suggesting
a physiological role as an incretin hormone, ie, being responsible, in part, for the higher insulin
secretory response after oral as compared to intravenous glucose administration. This ... Cited by 107 - Related articles - All 6 versions
