SE Kahn - Diabetologia, 2003 - Springer The relative contributions of insulin resistance and be- ta-cell dysfunction to the pathophysiology
of Type 2 diabetes have been debated extensively. The concept that a feedback loop governs
the interaction of the in- sulin-sensitive tissues and the beta cell as well as the elucidation ... Cited by 517 - Related articles - BL Direct - All 6 versions
- ►endojournals.org RL Hull, GT Westermark, P Westermark, SE … - Journal of Clinical …, 2004 - Endocrine Soc Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits contain
the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in humans have
demonstrated that islet amyloid is associated with loss of ß-cell mass, but a direct role for ... Cited by 120 - Related articles - BL Direct - All 6 versions
MR Hayden, SC Tyagi - Cardiovascular Diabetology, 2002 - cardiab.com Metabolic syndrome, insulin resistance, prediabetes, and overt type 2 diabetes mellitus are associated
with an accelerated atherosclerosis (atheroscleropathy). This quartet is also associated with
multiple metabolic toxicities resulting in the production of reactive oxygen species. The ... Cited by 57 - Related articles - Cached - All 14 versions
A Clark, MR Nilsson - Diabetologia, 2004 - Springer The role of islet amyloidosis in the onset and progres- sion of Type 2 diabetes remains
obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored and
co-released with insulin. Human islet amyloid polypeptide refolds to a β-conformation and ... Cited by 51 - Related articles - BL Direct - All 7 versions
MR Hayden, SC Tyagi - JOP. J Pancreas (Online), 2002 - joplink.net Conclusions Redox sensitive cellular signaling systems play an important role in the
development, progressive nature (remodeling) and damaging effects on the beta cell within the
islet of the pancreas. Furthermore, redox stress may play an important role in the ... Cited by 48 - Related articles - Cached - All 5 versions
S Luca, WM Yau, R Leapman, R Tycko - Biochemistry, 2007 - pubmedcentral.nih.gov The 37-residue amylin peptide, also known as islet amyloid polypeptide, forms fibrils that are
the main peptide or protein component of amyloid that develops in the pancreas of type 2 diabetes
patients. Amylin also readily forms amyloid fibrils in vitro that are highly polymorphic ... Cited by 46 - Related articles - All 2 versions
- ►diabetesjournals.org RL Hull, S Andrikopoulos, CB Verchere, J Vidal, F … - Diabetes, 2003 - Am Diabetes Assoc Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their
islet β-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic
mice developed islet amyloid when fed a breeder chow but not regular chow. Because ... Cited by 37 - Related articles - BL Direct - All 7 versions
- ►physiology.org JJ Meier, R Kayed, CY Lin, T Gurlo, L … - American Journal of …, 2006 - Am Physiological Soc Type 2 diabetes mellitus (T2DM) is characterized by an 60% deficit in -cell mass, increased
-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). Human IAPP
(hIAPP) forms oligomers, leading to either amyloid fibrils or toxic oligomers in an aqueous ... Cited by 33 - Related articles - BL Direct - All 3 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss
of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived
from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►nih.gov A Baumketner, JE Shea - Biophysical journal, 2005 - Elsevier The oligomerization of four peptide sequences, KFFE, KVVE, KLLE, and KAAE is studied using
replica-exchange molecular dynamics simulations with an atomically detailed peptide
model. Previous experimental studies reported that of these four peptides, only those ... Cited by 26 - Related articles - BL Direct - All 12 versions
