- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic
peptide (GIP) exert important effects on β-cells to stimulate glucose-dependent
insulin secretion. Both peptides also regulate β-cell proliferation and ... Cited by 283 - Related articles - All 13 versions
- ►stanford.edu [PDF] MK Badman, JS Flier - Science, 2005 - sciencemag.org In addition to digesting and assimilating nutrients, the intestine and
associated visceral organs play a key sensing and signaling role in the
physiology of energy homeostasis. The gut, the pancreatic islets of ... Cited by 161 - Related articles - All 14 versions
- ►physiology.org B Rolin, MO Larsen, CF Gotfredsen, CF … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc NN2211 is a long-acting, metabolically stable glucagon-like peptide-1 (GLP-1)
derivative designed for once daily administration in humans. NN2211 dose
dependently reduced the glycemic levels in ob/ob mice, with ... Cited by 128 - Related articles - BL Direct - All 4 versions
JG Kim, LL Baggio, DP Bridon, JP Castaigne, … - Diabetes, 2003 - Am Diabetes Assoc The rapid degradation of native glucagon-like peptide 1 (GLP-1) by dipeptidyl
peptidase-IV (DPP-IV) has fostered new approaches for generation of
degradation-resistant GLP-1 analogues. We examined the biological activity ... Cited by 126 - Related articles - BL Direct - All 5 versions
- ►physiology.org SC Woods - American Journal of Physiology- Gastrointestinal and …, 2004 - Am Physiological Soc An overview is presented of those signals generated by the gastrointestinal (GI)
tract during meals that interact with the central nervous system to create a
sensation of fullness and satiety. Although dozens of enzymes, hormones, ... Cited by 119 - Related articles - All 7 versions
DJ Drucker - eid, 2003 - informahealthcare.com Incretins are peptide hormones, exemplified by glucose-dependent insulino-
tropic peptide and glucagon-like peptide 1 that are released from the gut in
response to nutrient ingestion and enhance glucose-stimulated insulin ... Cited by 118 - Related articles - All 6 versions
- ►endojournals.org CL Dakin, CJ Small, RL Batterham, NM Neary … - Endocrinology, 2004 - Endocrine Soc Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from
cells of the gastrointestinal mucosa. Given intracerebroventricularly to rats,
it inhibits food intake and promotes weight loss. Here we report that ... Cited by 114 - Related articles - BL Direct - All 9 versions
CR Abbott, M Monteiro, CJ Small, A Sajedi, … - Brain Research, 2005 - Elsevier The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract
and the brain. A number of gastrointestinal hormones, including cholecystokinin
and ghrelin, require an intact vagal–brainstem–hypothalamic pathway to ... Cited by 100 - Related articles - All 3 versions
- ►diabetesjournals.org LL Baggio, Q Huang, TJ Brown, DJ Drucker - Diabetes, 2004 - Am Diabetes Assoc Peptide hormones exert unique actions via specific G protein–coupled
receptors; however, the therapeutic potential of regulatory peptides is
frequently compromised by rapid enzymatic inactivation and clearance from ... Cited by 94 - Related articles - BL Direct - All 11 versions
- Free from Publisher H Harder, L Nielsen, TDT Thi, A Astrup - Diabetes Care, 2004 - Am Diabetes Assoc RESULTS—After 8 weeks, liraglutide reduced fasting serum glucose (liraglutide,
−1.90 mmol/l, and placebo, 0.27 mmol/l; P = 0.002) and HbA 1c (liraglutide,
−0.33%, and placebo, 0.47%; P = 0.028) compared with placebo. No change ... Cited by 89 - Related articles - BL Direct - All 7 versions
