AA Mangi, N Noiseux, D Kong, H He, M … - Nature medicine, 2003 - sci.sdsu.edu Prolonged interruption of myocardial blood flow initiates events that culminate
in cardiac myocyte death1. Proposed endogenous reparative mechanisms include
cardiac myocyte hypertrophy2 and hyperplasia3 and the trafficking of bone ... Cited by 798 - Related articles - BL Direct - All 9 versions
- ►jbc.org JA Chavez, TA Knotts, LP Wang, G Li, RT … - Journal of Biological Chemistry, 2003 - ASBMB Multiple studies suggest that lipid oversupply to skeletal muscle contributes to
the development of insulin resistance, perhaps by promoting the accumulation of
lipid metabolites capable of inhibiting signal transduction. Herein we ... Cited by 156 - Related articles - BL Direct - All 5 versions
C De Alvaro, T Teruel, R Hernandez, M … - Journal of Biological Chemistry, 2004 - ASBMB Insulin stimulation produced a reliable 3-fold increase in glucose uptake in
primary neonatal rat myotubes, which was accompanied by a similar effect on
GLUT4 translocation to plasma membrane. Tumor necrosis factor (TNF)-α ... Cited by 142 - Related articles - BL Direct - All 4 versions
- ►jbc.org Y Tanaka, MV Gavrielides, Y Mitsuuchi, T … - Journal of Biological Chemistry, 2003 - ASBMB Activation of protein kinase C (PKC) by phorbol esters or diacylglycerol
mimetics induces apoptosis in androgen-dependent prostate cancer cells, an
effect that involves both the activation of the classic PKC and the novel ... Cited by 129 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in
insulin resistance, but the precise nature of the lipid species that produce
insulin resistance in human muscle are unknown. Ceramides, either generated ... Cited by 117 - Related articles - BL Direct - All 9 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
- ►physiology.org MW Hulver, JR Berggren, RN Cortright, RW … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The objectives of this study were to 1) examine skeletal muscle fatty acid
oxidation in individuals with varying degrees of adiposity and 2) determine the
relationship between skeletal muscle fatty acid oxidation and the ... Cited by 105 - Related articles - BL Direct - All 6 versions
- ►jbc.org S Stratford, KL Hoehn, F Liu, SA Summers - Journal of Biological Chemistry, 2004 - ASBMB The sphingolipid ceramide negatively regulates insulin action by inhibiting
Akt/protein kinase B (PKB), a serine/threonine kinase that is a central
regulator of glucose uptake and anabolic metabolism. Despite considerable ... Cited by 69 - Related articles - BL Direct - All 4 versions
M Straczkowski, I Kowalska, A Nikolajuk, S … - Diabetes, 2004 - Am Diabetes Assoc In vitro studies revealed that insulin resistance might be associated with the
intracellular formation of ceramide, the second messenger in the sphingomyelin
signaling pathway. The aim of the present study was to examine the content ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►jbc.org JA Chavez, WL Holland, J Bar, K Sandhoff, … - Journal of Biological Chemistry, 2005 - ASBMB Recent studies indicate that insulin resistance and type 2 diabetes result from
the accumulation of lipids in tissues not suited for fat storage, such as
skeletal muscle and the liver. To elucidate the mechanisms linking ... Cited by 55 - Related articles - All 6 versions
