- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of mechanisms
involved in the maintenance of normal glucose homeostasis in the basal or postabsorptive state
(10–12 h overnight fast) and following ingestion of a typical mixed meal [1, 2, 3, 4, 5, 6, 7, ... Cited by 694 - Related articles - BL Direct - All 5 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, … - Proceedings of the …, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell
dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal
muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and ... Cited by 667 - Related articles - BL Direct - All 15 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
S Kashyap, R Belfort, A Gastaldelli, T Pratipanawatr, R … - Diabetes, 2003 - Am Diabetes Assoc Acute elevations in free fatty acids (FFAs) stimulate insulin secretion, but prolonged lipid exposure
impairs β-cell function in both in vitro studies and in vivo animal studies. In humans data are
limited to short-term (≤48 h) lipid infusion studies and have led to conflicting results. We ... Cited by 156 - Related articles - BL Direct - All 4 versions
AE Civitarese, CP Jenkinson, D Richardson, M Bajaj, K … - Diabetologia, 2004 - Springer Aims/hypothesis. The recent discovery of two adiponectin receptors (AdipoR1 and AdipoR2)
will im- prove our understanding of the molecular mechanisms underlying the insulin-sensitising
effect of adiponec- tin. The aim of this study was to determine for the first time whether ... Cited by 144 - Related articles - BL Direct - All 4 versions
- ►edulife.com.br [PDF] PJ Miranda, RA DeFronzo, RM Califf, JR Guyton - American Heart Journal, 2005 - Elsevier In 1988, Reaven 1 proposed that insulin resistance is central to the etiology of type 2 diabetes
mellitus, hypertension, and coronary artery disease. The concept of insulin resistance and associated
metabolic abnormalities leading to increased risk of cardiovascular disease became ... Cited by 120 - Related articles - All 13 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E Wang, RA … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in insulin
resistance, but the precise nature of the lipid species that produce insulin resistance in human
muscle are unknown. Ceramides, either generated via activation of sphingomyelinase or ... Cited by 118 - Related articles - BL Direct - All 9 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many different elements
that act in concert to cause that disease. This review proposes a sequence of events and how
they interact by a careful analysis of the human and animal model literature. A genetic ... Cited by 102 - Related articles - All 14 versions
- ►diabetesjournals.org K Bouzakri, M Roques, P Gual, S Espinosa, F Guebre- … - Diabetes, 2003 - Am Diabetes Assoc To understand better the defects in the proximal steps of insulin signaling during type 2
diabetes, we used differentiated human skeletal muscle cells in primary culture. When compared
with cells from control subjects, myotubes established from patients with type 2 diabetes ... Cited by 98 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM Olefsky - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance is predominantly characterized by decreased insulin-stimulated glucose uptake
into skeletal muscle. In the current study, we have assessed various aspects of the phosphatidylinositol
(PI) 3-kinase pathway in skeletal muscle biopsies obtained from normal, obese ... Cited by 80 - Related articles - BL Direct - All 5 versions
