S Yamagishi, T Imaizumi - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: Diabetic vascular complication is a leading cause of end-stage renal
failure, acquired blindness, a variety of neuropathies and accelerated
atherosclerosis, which could account for disabilities and high mortality ... Cited by 123 - Related articles - All 3 versions
EWM Ng, AP Adamis - Canadian Journal of Ophthalmology, 2005 - medplus-pm.net Angiogenesis has a causal role in many diseases, including neovascular
age-related macular degeneration (AMD). Identification of key regulators of
angiogenesis, including vascular endothelial growth factor (VEGF), ... Cited by 111 - Related articles - All 4 versions
N Bouck - Trends in molecular medicine, 2002 - Elsevier Sight-threatening eye diseases can be caused and exacerbated by the aberrant
growth of new blood vessels. Recent work indicates that this neovascularization
not only is a response to a rise in the local concentration of molecules ... Cited by 107 - Related articles - All 12 versions
LP Aiello - Survey of ophthalmology, 2002 - Elsevier Diabetic retinopathy is one of the most debilitating complications of diabetes
mellitus. Despite major advances in understanding the pathogenesis of this
disease and the efficacy of current therapies, diabetic retinopathy remains ... Cited by 90 - Related articles - All 9 versions
S Yamagishi, Y Inagaki, S Amano, T Okamoto, … - Biochemical and biophysical research communications, 2002 - Elsevier Pigment epithelium-derived factor (PEDF) has recently been shown to be the most
potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of
PEDF is involved in the pathogenesis of proliferative diabetic retinopathy. ... Cited by 89 - Related articles - BL Direct - All 9 versions
EJ Duh, HS Yang, JA Haller, E De Juan, MS … - American journal of ophthalmology, 2004 - Elsevier The VEGF levels were at or below the level of detectability in the reference and
choroidal neovascularization groups. The VEGF levels were significantly elevated
in both the active and inactive PDR groups, and significantly higher in the ... Cited by 79 - Related articles - All 14 versions
H Liu, JG Ren, WL Cooper, CE Hawkins, MR … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences Vascular permeability plays a key role in a wide array of life-threatening and
sight-threatening diseases. Vascular endothelial growth factor can increase
vascular permeability. Using a model system for nonproliferative diabetic ... Cited by 73 - Related articles - BL Direct - All 16 versions
L Wang, V Schmitz, A Perez-Mediavilla, I Izal, … - Molecular Therapy, 2003 - Elsevier Pigment epithelium-derived factor (PEDF) was identified from retinal pigment
epithelial cells and has been shown to display neurotrophic effects. In addition
it has been found to induce a potent inhibition of angiogenesis. In this ... Cited by 66 - Related articles - All 4 versions
JL Wilkinson-Berka - Current pharmaceutical design, 2004 - ingentaconnect.com Abstract: The pathogenetic agents involved in the development of diabetic
retinopathy are diverse. In the setting of hyperglycaemia and retinal hypoxia a
number of vasoactive factors may interact to promote pathology in a variety ... Cited by 66 - Related articles - BL Direct - All 5 versions
- ►iovs.org C Shao, J Sima, SX Zhang, J Jin, P Reinach, … - Investigative ophthalmology & visual science, 2004 - ARVO RESULTS. Soluble proteins from HAM inhibited proliferation of human umbilical
vein endothelial cells and bovine retinal capillary endothelial cells (BRCECs)
while promoting proliferation of bovine cornea epithelial cells. Moreover, ... Cited by 62 - Related articles - BL Direct - All 5 versions
