EMD Nielsen, L Hansen, B Carstensen, SM … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Cited by 146 - Related articles - BL Direct - All 5 versions
- ►umdnj.edu [PDF] AA Dunn-Meynell, VH Routh, L Kang, L … - Diabetes, 2002 - Am Diabetes Assoc Specialized neurons utilize glucose as a signaling molecule to alter their
firing rate. Glucose-excited (GE) neurons increase and glucose-inhibited (GI)
neurons reduce activity as ambient glucose levels rise. Glucose-induced ... Cited by 116 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org R Wang, X Liu, ST Hentges, AA Dunn-Meynell … - Diabetes, 2004 - Am Diabetes Assoc Glucosensing neurons in the hypothalamic arcuate nucleus (ARC) were studied
using electrophysiological and immunocytochemical techniques in neonatal male
Sprague-Dawley rats. We identified glucose-excited and -inhibited neurons, ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►voeljemens.nl [PDF] A Peters, U Schweiger, L Pellerin, C Hubold, … - Neuroscience and biobehavioral reviews, 2004 - Elsevier The brain occupies a special hierarchical position in the organism. It is
separated from the general circulation by the blood-brain barrier, has high
energy consumption and a low energy storage capacity, uses only specific ... Cited by 97 - Related articles - All 8 versions
- ►rutgers.edu [PDF] L Kang, VH Routh, EV Kuzhikandathil, LD … - Diabetes, 2004 - Am Diabetes Assoc To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging
and single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic
nucleus (VMN) neurons. Glucose-excited (GE) neurons increased and glucose- ... Cited by 94 - Related articles - BL Direct - All 7 versions
VH Routh - Physiology and Behavior, 2002 - zlab.rutgers.edu Glucose homeostasis is of paramount concern to the brain since glucose is its
primary fuel. Thus, the brain has evolved mechanisms to sense and respond to
changes in glucose levels. The efferent aspects of the central nervous ... Cited by 83 - Related articles - View as HTML - BL Direct - All 5 versions
- ►nih.gov L Plum, BF Belgardt, JC Brüning - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Insulin has pleiotropic biological effects in virtually all tissues. However,
the relevance of insulin signaling in peripheral tissues has been studied far
more extensively than its role in the brain. An evolving body of evidence ... Cited by 75 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org ML Evans, RJ McCrimmon, DE Flanagan, T … - Diabetes, 2004 - Am Diabetes Assoc It has been postulated that specialized glucose-sensing neurons in the
ventromedial hypothalamus (VMH) are able to detect falling blood glucose and
trigger the release of counterregulatory hormones during hypoglycemia. The ... Cited by 74 - Related articles - BL Direct - All 5 versions
C Messier - European journal of pharmacology, 2004 - Elsevier Glucose improvement of memory appears to involve two optimal doses in animals
(100 mg/kg and 2 g/kg) that may correspond to two physiological mechanisms
underlying glucose effects on memory. In humans, there have been few dose– ... Cited by 69 - Related articles - All 4 versions
- ►nih.gov B Xue, BB Kahn - The Journal of physiology, 2006 - Physiological Soc The evolutionarily conserved serine/threonine kinase, AMP-activated protein
kinase (AMPK), functions as a cellular fuel gauge that regulates metabolic
pathways in glucose and fatty acid metabolism and protein synthesis. Recent ... Cited by 70 - Related articles - BL Direct - All 8 versions
