MMW Chong, HE Thomas, TWH Kay - Journal of Biological Chemistry, 2002 - ASBMB Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of the
Jak-STAT (signal transducer and activator of transcription cytokine) signaling
pathway but may also regulate other pathways. At least in vitro, SOCS-1 ... Cited by 55 - Related articles - BL Direct - All 5 versions
M Flodström-Tullberg, D Yadav, R Hägerkvist, … - Diabetes, 2003 - Am Diabetes Assoc Although lymphocyte infiltration and islet destruction are hallmarks of
diabetes, the mechanisms of β-cell destruction are not fully understood. One
issue that remains unresolved is whether cytokines play a direct role in ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL Dudek, … - The Journal of Immunology, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell
destruction by direct cytotoxicity, inducing Fas expression, and up-regulating
class I MHC and chemokine expression to increase immune recognition. To ... Cited by 37 - Related articles - BL Direct - All 4 versions
CA Gysemans, L Ladrière, H Callewaert, J … - Diabetes, 2005 - Am Diabetes Assoc The main focus in studies on the pathogenesis of autoimmune type 1 diabetes has
been on the role of the immune system, with much less attention directed to the
target of the immune assault, namely the insulin-secreting β-cells. ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org R Darwiche, MMW Chong, P Santamaria, HE … - The Journal of Immunology, 2003 - Am Assoc Immnol Fas (CD95) is a potential mechanism of pancreatic cell death in type 1 diabetes.
cells do not constitutively express Fas but it is induced by cytokines. The
hypothesis of this study is that Fas expression should be measurable on ... Cited by 24 - Related articles - BL Direct - All 4 versions
NL Dudek, HE Thomas, L Mariana, RM … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-cells are the major mediators of β-cell destruction in type 1
diabetes, but the molecular mechanisms are not definitively established. We have
examined the contribution of perforin and Fas ligand to β-cell destruction ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org MD McKenzie, NL Dudek, L Mariana, MMW … - International immunology, 2006 - Jpn Soc Immunol Direct interaction between auto-reactive CTL and specific peptide–MHC class I
complexes on pancreatic beta cells is critical in mediating beta cell
destruction in type I diabetes. We used mice with genetic modifications in ... Cited by 19 - Related articles - All 4 versions
- ►eje-online.org C Santangelo, A Scipioni, L Marselli, P … - European journal of endocrinology, 2005 - EFES Objective: Suppressor of cytokine signaling (SOCS) proteins negatively regulate
signal transduction of several cytokines. Since cytokines participate in the
pancreatic islet damage in type 1 diabetes, the aim of our study was to ... Cited by 15 - Related articles - All 9 versions
SG Rønn, N Billestrup, T Mandrup-Poulsen - Diabetes, 2007 - Am Diabetes Assoc The pathogenesis of type 1 diabetes is not clearly understood, but it is
generally accepted that type 1 diabetes is an immune-mediated disease caused by
inflammation in the islets of Langerhans. Infiltrating macrophages release ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►jneurosci.org R Balabanov, K Strand, A Kemper, JY Lee, B … - Journal of Neuroscience, 2006 - Soc Neuroscience Interferon- (IFN- ) is a pleiotropic cytokine produced by T cells and natural
killer cells that has been implicated as a deleterious factor in the
immune-mediated demyelinating disorder multiple sclerosis. In vitro, ... Cited by 15 - Related articles - BL Direct - All 5 versions
