RM Seaberg, SR Smukler, TJ Kieffer, G … - Nature Biotechnology, 2004 - utoronto.ca The clonal isolation of putative adult pancreatic precursors has been an elusive
goal of researchers seeking to develop cell replacement strategies for diabetes.
We report the clonal identification of multipotent precursor cells from the ... Cited by 262 - Related articles - BL Direct - All 13 versions
- ►endojournals.org L Farilla, A Bulotta, B Hirshberg, S Li Calzi, … - Endocrinology, 2003 - Endocrine Soc The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase
glucose-dependent insulin secretion, enhance insulin gene transcription, expand
islet cell mass, and inhibit ß-cell apoptosis in animal models of ... Cited by 217 - Related articles - BL Direct - All 5 versions
- ►amjpathol.org T Fujikawa, SH Oh, L Pi, HM Hatch, T Shupe, … - American Journal of Pathology, 2005 - ASIP Embryonic stem (ES) cells have been proposed to be a powerful tool in the study
of pancreatic disease, as well as a potential source for cell replacement
therapy in the treatment of diabetes. However, data demonstrating the ... Cited by 138 - Related articles - All 8 versions
C Ricordi - Diabetes, 2003 - medscape.com It has indeed been a distinct honor to be the recipient of the 2002 Outstanding
Scientific Achievement Award, and I was happy to accept it, on behalf of the
entire islet transplant field, as there have been many surgeons, ... Cited by 100 - Related articles - All 8 versions
H Funakoshi, T Nakamura - Clinica Chimica Acta, 2003 - Elsevier Hepatocyte growth factor (HGF), initially identified and molecularly cloned as a
potent mitogen of primary cultured hepatocytes, has multiple activities in a
variety of tissues during the course of development and also in various ... Cited by 91 - Related articles - All 4 versions
- ►nih.gov A Suzuki, H Nakauchi, H Taniguchi - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Glucagon-like peptide (GLP) 1 is produced through posttranslational processing
of proglucagon and acts as a regulator of various homeostatic events. Among its
analogs, however, the function of GLP-1-(1–37), synthesized in small ... Cited by 68 - Related articles - All 9 versions
- ►endojournals.org JC Lopez-Talavera, A Garcia-Ocana, I Sipula, … - Endocrinology, 2004 - Endocrine Soc Islet transplantation for diabetes is limited by the availability of human islet
donors. Hepatocyte growth factor (HGF) is a potent ß-cell mitogen and survival
factor and improves islet transplant outcomes in a murine model. However, ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint
is the retinoblastoma protein (pRb), and this is regulated in part by the
activities of cyclin-dependent kinase (cdk)-4 and the D cyclins. ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►jbc.org A Garcia-Ocana, KK Takane, VT Reddy, JC … - Journal of Biological Chemistry, 2003 - ASBMB Hepatocyte growth factor (HGF) increases beta cell proliferation and function in
rat insulin promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also
function superiorly to normal islets in a transplant setting. Here, we ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
