- ►shouxi.net T Otonkoski, K Näntö-Salonen, M Seppänen, … - Diabetes, 2006 - Am Diabetes Assoc Congenital hyperinsulinism of infancy (CHI) is characterized by severe
hypoglycemia due to dysregulated insulin secretion, associated with either focal
or diffuse pathology of the endocrine pancreas. The focal condition is ... Cited by 77 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint
is the retinoblastoma protein (pRb), and this is regulated in part by the
activities of cyclin-dependent kinase (cdk)-4 and the D cyclins. ... Cited by 57 - Related articles - BL Direct - All 4 versions
C Sempoux, Y Guiot, K Dahan, P Moulin, M … - Diabetes, 2003 - Am Diabetes Assoc Paternal mutation of ATP-sensitive K + (K ATP ) channel genes and loss of
heterozygosity (LOH) of the 11p15 region including the maternal alleles of
ABCC8, IGF2, and CDKN1C characterize the focal form of persistent ... Cited by 56 - Related articles - BL Direct - All 6 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
OT Hardy, M Hernandez-Pampaloni, JR Saffer, … - The Journal of Pediatrics, 2007 - Elsevier The diagnosis of focal or diffuse hyperinsulinism was correct in 23 of the 24
cases (96%) and equivocal in 1 case. [ 18 F]-DOPA PET identified focal areas of
high uptake of radiopharmaceutical in 11 patients. Pathology results ... Cited by 44 - Related articles - All 14 versions
- ►endocrinology-journals.org AM Ackermann, M Gannon - Journal of molecular endocrinology, 2007 - Soc Endocrinology Pancreatic ß-cells are responsible for producing all of the insulin required by
an organism to maintain glucose homeostasis. Defects in development,
maintenance, or expansion of ß-cell mass can result in impaired glucose ... Cited by 35 - Related articles - All 4 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►endojournals.org OT Hardy, M Hernandez-Pampaloni, JR Saffer, … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Results: The diagnosis of focal or diffuse HI was correct in 44 of the 50 cases
(88%). [ 18 F]DOPA PET identified focal areas of high uptake of
radiopharmaceutical in 18 of 24 patients with focal disease. The locations ... Cited by 22 - Related articles - BL Direct - All 3 versions
JC Fournet, C Junien - Endocrine Pathology, 2004 - Springer Abstract Congenital hyperinsulinism (CHI) is a clinically and genetically
heterogeneous entity and causes severe hypoglycemia in neonates and infants. The
clinical heterogeneity is mani- fested by severity ranging from extremely ... Cited by 18 - Related articles - All 3 versions
- ►endojournals.org K Hussain, KE Cosgrove, RM Shepherd, A … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Background: Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth
syndrome that is clinically and genetically heterogeneous. Hyperinsulinemic
hypoglycemia occurs in about 50% of children with BWS and, in the majority ... Cited by 18 - Related articles - BL Direct - All 5 versions
