- ►nih.gov MW Rajala, S Obici, PE Scherer, L Rossetti - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig The adipose-derived hormone resistin is postulated to link obesity to insulin
resistance and diabetes. Here, the infusion of either resistin or the
resistin-like molecule–β (RELMβ) rapidly induced severe hepatic but not ... Cited by 382 - Related articles - BL Direct - All 9 versions
- ►jbc.org VT Samuel, ZX Liu, X Qu, BD Elder, S Bilz, D … - Journal of Biological Chemistry, 2004 - ASBMB Short term high fat feeding in rats results specifically in hepatic fat
accumulation and provides a model of non-alcoholic fatty liver disease in which
to study the mechanism of hepatic insulin resistance. Short term fat ... Cited by 339 - Related articles - BL Direct - All 6 versions
- ►nih.gov ED Muse, S Obici, S Bhanot, BP Monia, RA … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Resistin is an adipose-derived hormone postulated to link adiposity to insulin
resistance. To determine whether resistin plays a causative role in the
development of diet-induced insulin resistance, we lowered circulating ... Cited by 193 - Related articles - BL Direct - All 10 versions
- ►endocrinology-journals.org [PDF] J Ren - Journal of Endocrinology, 2004 - Soc Endocrinology The obese gene product, leptin, plays a central role in food intake and energy
metabolism. The physiological roles of leptin in human bodily function have been
broadened over the past decade since leptin was first discovered in 1994. ... Cited by 125 - Related articles - BL Direct - All 10 versions
TKT Lam, GJ Schwartz, L Rossetti… - Nature neuroscience, 2005 - dept.wofford.edu Energy homeostasis is maintained by multiple mechanisms that gather information
on the body's nutritional status and make appro- priate behavioral and metabolic
responses to changes in fuel avail- ability. Although it is clear that ... Cited by 119 - Related articles - All 5 versions
- ►yu.edu [PDF] TKT Lam, A Pocai, R Gutierrez-Juarez, S Obici … - Nature medicine, 2005 - medscape.com Increased glucose production is a hallmark of type 2 diabetes and alterations in
lipid metabolism have a causative role in its pathophysiology. Here we postulate
that physiological increments in plasma fatty acids can be sensed within ... Cited by 117 - Related articles - All 9 versions
- ►endojournals.org DS Weigle, DE Cummings, PD Newby, PA … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Loss of body fat by caloric restriction is accompanied by decreased circulating
leptin levels, increased ghrelin levels, and increased appetite. In contrast,
dietary fat restriction often decreases adiposity without increasing ... Cited by 117 - Related articles - BL Direct - All 5 versions
- ►physiology.org BE Levin, AA Dunn-Meynell, WA Banks - … Journal of Physiology- Regulatory, Integrative and …, 2004 - Am Physiological Soc Rats selectively bred to develop diet-induced obesity (DIO) were compared with
those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard
to their central leptin signaling and blood-brain barrier (BBB) transport. ... Cited by 115 - Related articles - BL Direct - All 6 versions
- ►endojournals.org S Obici, L Rossetti - Endocrinology, 2003 - Endocrine Soc Obesity is the result of an imbalance between energy intake and energy
expenditure. Under most circumstances, the increased availability of nutrients
is tightly coupled with nutrient-sensing mechanisms that in turn activate ... Cited by 109 - Related articles - BL Direct - All 5 versions
KD Niswender, DG Baskin, MW Schwartz - Trends in Endocrinology & Metabolism, 2004 - Elsevier Despite an alarming increase in the burden of obesity worldwide, body adiposity
seems to be a regulated physiological variable. Regulation of adiposity occurs
through a classical endocrine feedback loop, in which the pancreatic ... Cited by 103 - Related articles - All 8 versions
