P Ferré - Diabetes, 2004 - Am Diabetes Assoc Peroxisome proliferator-activated receptors (PPARs) are transcription factors
belonging to the superfamily of nuclear receptors. Three isoforms (α, δ, and
γ) have been described. They act on DNA response elements as heterodimers ... Cited by 250 - Related articles - BL Direct - All 7 versions
- ►nih.gov P Lefebvre, G Chinetti, JC Fruchart, B Staels - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid
metabolism as well as glucose homeostasis. Acting as a molecular sensor of
endogenous fatty acids (FAs) and their derivatives, this ligand-activated ... Cited by 205 - Related articles - BL Direct - All 9 versions
JN Feige, L Gelman, L Michalik, B Desvergne … - Progress in Lipid Research, 2006 - Elsevier Peroxisome proliferator-activated receptors (PPARs) compose a family of three
nuclear receptors which act as lipid sensors to modulate gene expression. As
such, PPARs are implicated in major metabolic and inflammatory regulations ... Cited by 156 - Related articles - All 2 versions
- ►endojournals.org B Desvergne, L Michalik, W Wahli - Molecular Endocrinology, 2004 - Endocrine Soc Investigating metabolism by unveiling the functions of the nuclear receptors
peroxisome proliferator-activated receptors (PPARs) in the numerous intricate
pathways ensuring energy homeostasis and fitness has been extremely ... Cited by 129 - Related articles - BL Direct - All 8 versions
J An, DM Muoio, M Shiota, Y Fujimoto, GW … - Nature medicine, 2004 - nature.com Lipid infusion or ingestion of a high-fat diet results in insulin resistance,
but the mechanism underlying this phenomenon remains unclear. Here we show that,
in rats fed a high-fat diet, whole-animal, muscle and liver insulin ... Cited by 118 - Related articles - BL Direct - All 5 versions
- ►cell.com TR Koves, JR Ussher, RC Noland, D Slentz, … - Cell metabolism, 2008 - Elsevier Previous studies have suggested that insulin resistance develops secondary to
diminished fat oxidation and resultant accumulation of cytosolic lipid molecules
that impair insulin signaling. Contrary to this model, the present study ... Cited by 117 - Related articles - All 9 versions
- ►nih.gov T Hajri, XX Han, A Bonen, NA Abumrad - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Deficiency of the membrane protein FAT/CD36 causes a marked defect in fatty acid
uptake by various tissues and is genetically linked to insulin resistance in
rats and humans. Here, we examined insulin responsiveness of CD36 –/– ... Cited by 109 - Related articles - BL Direct - All 11 versions
- ►jbc.org TR Koves, P Li, J An, T Akimoto, D Slentz, … - Journal of Biological Chemistry, 2005 - ASBMB Peroxisome proliferator-activated receptor- co-activator 1 (PGC1 ) is a
promiscuous co-activator that plays a key role in regulating mitochondrial
biogenesis and fuel homeostasis. Emergent evidence links decreased skeletal ... Cited by 103 - Related articles - BL Direct - All 4 versions
C Bernal-Mizrachi, S Weng, C Feng, BN … - Nature medicine, 2003 - mechamlab.wustl.edu Glucocorticoids are among the most commonly prescribed medica- tions. Their
anti-inflammatory properties are crucial for people with organ transplants,
asthma, malignancies, rheumatologic syndromes, vision-threatening eye ... Cited by 102 - Related articles - BL Direct - All 10 versions
