H Ruan, HF Lodish - Cytokine and Growth Factor Reviews, 2003 - Elsevier Insulin resistance is a fundamental defect that precedes the development of the
full insulin resistance syndrome as well as β cell failure and type 2 diabetes.
Tumor necrosis factor-α (TNF-α), a paracrine/autocrine factor highly ... Cited by 237 - Related articles - All 10 versions
HP Guan, Y Li, MV Jensen, CB Newgard, CM … - Nature medicine, 2002 - med.upenn.edu Obesity and type 2 diabetes are epidemic in industrialized soci- eties1.
Metabolic dysregulation is a hallmark of diabetes, but for many years the fat
cell was viewed largely as a depository for fuel in the form of fatty acids ... Cited by 197 - Related articles - View as HTML - BL Direct - All 11 versions
H Ruan, PDG Miles, CM Ladd, K Ross, TR … - Diabetes, 2002 - Am Diabetes Assoc Despite extensive studies implicating tumor necrosis factor (TNF)-α as a
contributing cause of insulin resistance, the mechanism(s) by which TNF-α
alters energy metabolism in vivo and the tissue specificity of TNF-α ... Cited by 155 - Related articles - BL Direct - All 6 versions
- ►jbc.org H Ruan, HJ Pownall, HF Lodish - Journal of Biological Chemistry, 2003 - ASBMB Troglitazone (TGZ), a member of the thiazolidinedione class of anti-diabetic
compounds and a peroxisome proliferator activator receptor- (PPAR- ) agonist,
restores systemic insulin sensitivity and improves the full insulin ... Cited by 85 - Related articles - BL Direct - All 6 versions
- ►nih.gov T Hibuse, N Maeda, T Funahashi, K Yamamoto, … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences In adipocytes, hydrolysis of triglycerides results in the release of free fatty
acids and glycerol. Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known
to permeabilize glycerol and water. We recently generated Aqp7-knockout ... Cited by 75 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org PJ Voshol, MC Jong, VEH Dahlmans, D Kratky … - Diabetes, 2001 - Am Diabetes Assoc In patients with type 2 diabetes, a strong correlation between accumulation of
intramuscular triclycerides (TGs) and insulin resistance has been found. The aim
of the present study was to determine whether there is a causal relation ... Cited by 66 - Related articles - BL Direct - All 9 versions
F Kamp, W Guo, R Souto, PF Pilch, BE Corkey … - Journal of Biological Chemistry, 2003 - ASBMB Nonesterified long-chain fatty acids may enter cells by free diffusion or by
membrane protein transporters. A requirement for proteins to transport fatty
acids across the plasma membrane would imply low partitioning of fatty ... Cited by 54 - Related articles - BL Direct - All 4 versions
GM Hatch - Biochemistry and Cell Biology, 2004 - article.pubs.nrc-cnrc.gc.ca Abstract: Phospholipids are important structural and functional components of
all biological membranes and define the compartmentation of organelles.
Mitochondrial phospholipids comprise a significant proportion of the entire ... Cited by 47 - Related articles - BL Direct - All 8 versions
- ►cell.com AK Agarwal, A Garg - Trends in Endocrinology & Metabolism, 2003 - Elsevier Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive
disorder characterized by marked lack of body fat since birth, which results in
striking muscular appearance. Patients develop extreme insulin resistance ... Cited by 46 - Related articles - All 8 versions
J Magré, M Delépine, L Van Maldergem, JJ … - Diabetes, 2003 - Am Diabetes Assoc Berardinelli-Seip congenital lipodystrophy (BSCL) is a heterogeneous genetic
disease characterized by near absence of adipose tissue and severe insulin
resistance. We have previously identified mutations in the seipin gene in a ... Cited by 38 - Related articles - BL Direct - All 5 versions
