- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus
in ro- dents and possibly in humans. Clarification of the regulation of beta-cell death could indicate
novel sites for therapeutic intervention in Type I (insulin- dependent) diabetes mellitus. ... Cited by 323 - Related articles - BL Direct - All 6 versions
H Kleinert, A Pautz, K Linker, PM Schwarz - European journal of pharmacology, 2004 - Elsevier The role of nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase
(iNOS) is very complex. Induction of iNOS expression and hence NO production has been described
to have beneficial antiviral, antiparasital, microbicidal, immunomodulatory, and ... Cited by 271 - Related articles - BL Direct - All 13 versions
- ►jimmunol.org L Wen, J Peng, Z Li, FS Wong - The Journal of Immunology, 2004 - Am Assoc Immnol Viral infections have previously been implicated as a trigger of autoimmune diabetes. In this
study, we compared a viral mimic with other microbial components derived from bacteria in triggering
diabetes development in C57BL/6-rat insulin promoter-B7.1 mice that do not normally ... Cited by 60 - Related articles - All 4 versions
- ►endojournals.org D Liu, AK Cardozo, MI Darville, DL Eizirik - Endocrinology, 2002 - Endocrine Soc Viral infections may trigger the autoimmune assault leading to type 1 diabetes mellitus.
Double-stranded RNA (dsRNA) is produced by many viruses during their replicative cycle. The
dsRNA, tested as synthetic poly(IC) (PIC), in synergism with the proinflammatory ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org M Flodstrom-Tullberg, M Hultcrantz, A … - The Journal of …, 2005 - Am Assoc Immnol Coxsackievirus (CV) is an important human pathogen that has been linked to the development
of autoimmunity. An intact pancreatic cell IFN response is critical for islet cell survival and protection
from type 1 diabetes following CV infection. In this study, we show that IFNs trigger an ... Cited by 34 - Related articles - All 4 versions
- ►amjpathol.org AL Scarim, M Arnush, LA Blair, J Concepcion, MR … - American Journal of …, 2001 - ASIP Viral infection is one environmental factor that has been implicated as a precipitating event that
may initiate ß-cell damage during the development of diabetes. This study examines the mechanisms
by which the viral replicative intermediate, double-stranded (ds) RNA impairs ß-cell ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org SA Steer, JM Moran, LB Maggi Jr, RML … - The Journal of …, 2003 - Am Assoc Immnol In this study the regulation of macrophage expression of cyclooxygenase-2 (COX-2) in response
to dsRNA and virus infection was examined. Treatment of RAW 264.7 macrophages with dsRNA
results in COX-2 mRNA accumulation and protein expression and the production of PGE ... Cited by 32 - Related articles - BL Direct - All 4 versions
- ►nih.gov CJ Auch, RN Saha, FG Sheikh, X Liu, BL Jacobs, K … - FEBS letters, 2004 - Elsevier Environmental factor(s), such as viral infection, has been implicated as one of the triggering events
leading to neuroinflammation in multiple sclerosis. This study underlines the importance of
double-stranded RNA (dsRNA), the active component of a viral infection, in inducing the ... Cited by 26 - Related articles - All 9 versions
- ►jbc.org LA Blair, LB Maggi Jr, AL Scarim, JA Corbett - Journal of Biological Chemistry, 2002 - ASBMB Environmental factors, such as viral infection, have been implicated as potential triggering events
leading to the initial destruction of pancreatic cells during the development of autoimmune
diabetes. Double-stranded RNA (dsRNA), the active component of a viral infection that ... Cited by 27 - Related articles - BL Direct - All 4 versions
