- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological …, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided by Laidlaw in
1938 who used the term nesidioblastosis to describe the severe, recurrent hypoglycemia associated
with an inappropriate elevation of serum insulin, C-peptide, and proinsulin (161). While ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►endocrinology-journals.org [PDF] A Trumper, K Trumper, D Horsch - Journal of Endocrinology, 2002 - Soc Endocrinology Glucose-dependent insulinotropic polypeptide (GIP) acts as a glucose-dependent growth factor
for -cells. Here we show that GIP and glucose also act synergistically as anti-apoptotic factors
for -cells, using the well- differentiated -cell line, INS-1. Mitogenic and anti-apoptotic ... Cited by 102 - Related articles - BL Direct - All 4 versions
PE MacDonald, W El-kholy, MJ Riedel, AMF Salapatek, … - Diabetes, 2002 - Am Diabetes Assoc The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest because
of the potential clinical relevance of this peptide. Produced in intestinal L-cells through posttranslational
processing of the proglucagon gene, GLP-1 is released from the gut in response to ... Cited by 95 - Related articles - BL Direct - All 4 versions
LE Fridlyand, LH Philipson - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulin secretion (GDIS), reactive oxygen species (ROS) production, and
oxidative stress in pancreatic β-cells may be tightly linked processes. Here we suggest that the
same pathways used in the activation of GDIS (increased glycolytic flux, ATP-to-ADP ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org CB Wollheim, P Maechler - Diabetes, 2002 - Am Diabetes Assoc The β-cell mitochondria are known to generate metabolic coupling factors, or messengers, that
mediate plasma membrane depolarization and the increase in cytosolic Ca 2+ , the triggering
event in glucose-stimulated insulin secretion. Accordingly, ATP closes ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►endojournals.org PE Light, M Fox, E Jocelyn, MJ Riedel, MB … - Molecular …, 2002 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) elicits a glucose-dependent insulin secretory effect via elevation
of cAMP and activation of protein kinase A (PKA). GLP-1-mediated closure of ATP-sensitive potassium
(K ATP ) channels is involved in this process, although the mechanism of action of PKA ... Cited by 41 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org IR Sweet, DL Cook, E DeJulio, AR Wallen, G Khalil, J … - Diabetes, 2004 - Am Diabetes Assoc ATP and ADP levels are critical regulators of glucose-stimulated insulin secretion. In many aerobic
cell types, the phosphorylation potential (ATP/ADP/P i ) is controlled by sensing mechanisms
inherent in mitochondrial metabolism that feed back and induce compensatory changes ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►thelightlab.ca [PDF] MJ Riedel, DC Steckley, PE Light - Human genetics, 2005 - Springer Abstract The ATP-sensitive potassium (KATP) channel couples membrane excitability to cellular
metabolism and is a critical mediator in the process of glucose- stimulated insulin secretion. Increasing
numbers of KATP channel polymorphisms are being described and linked to altered ... Cited by 33 - Related articles - All 5 versions
P Krippeit-Drews, M Bäcker, M Düfer, G Drews - Pflügers Archiv European …, 2003 - Springer Abstract The aim of the present study was to test the hypothesis that a creatine kinase/phosphocreatine
system is involved in the regulation of K ATP channels in pancreatic b-cells. The phosphocreatine
concentration in isolated mouse islets clearly increased in parallel with the ATP/ADP ratio ... Cited by 17 - Related articles - BL Direct - All 3 versions
LE Fridlyand, LH Philipson - Current Diabetes Reviews, 2006 - ingentaconnect.com Abstract: Insulin resistance (IRe) and a failure of insulin secretion are the major features of the
early pathophysiology of type-2 diabetes mellitus (T2D) but the etiology is still not well
understood. We suggest that: 1. The cellular mechanisms that protect against oxidative ... Cited by 15 - Related articles - BL Direct - All 2 versions
