AE Butler, J Janson, S Bonner-Weir, R Ritzel, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by impaired insulin secretion. Some but not all
studies suggest that a decrease in β-cell mass contributes to this. We examined
pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m 2 ; 41 ... Cited by 950 - Related articles - BL Direct - All 4 versions
S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
- ►diabetesjournals.org GC Weir, S Bonner-Weir - Diabetes, 2004 - Am Diabetes Assoc This article proposes five stages in the progression of diabetes, each of which
is characterized by different changes in ß-cell mass, phenotype, and function.
Stage 1 is compensation: insulin secretion increases to maintain ... Cited by 161 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Gao, J Ustinov, MA Pulkkinen, K Lundin, O … - Diabetes, 2003 - Am Diabetes Assoc We have reproduced a previously described method for the in vitro generation of
endocrine cells in adult human pancreatic tissue culture. The aim of this study
was to characterize the nature of pancreatic progenitor cells and to ... Cited by 154 - Related articles - BL Direct - All 7 versions
AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass.
In contrast, obese humans with type 2 diabetes have an ∼60% deficit in β-cell
mass. Recent studies in rodents reveal that β-cell mass is regulated, ... Cited by 145 - Related articles - BL Direct - All 6 versions
- ►psu.edu [PDF] RA Ritzel, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by a relative β-cell deficit as a result of
increased β-cell apoptosis and islet amyloid derived from the β-cell peptide
islet amyloid polypeptide (IAPP). Human IAPP (h-IAPP) but not mouse IAPP ... Cited by 73 - Related articles - BL Direct - All 9 versions
- ►eje-online.org [PDF] H Hui, R Perfetti - European journal of endocrinology, 2002 - EFES Pancreas duodenum homeobox-1 (PDX-1) (also known as insulin promoter factor-1,
islet/duodenum homeobox-1, somatostatin transactivating factor-1, insulin
upstream factor-1 and glucose-sensitive factor) is a transcription factor ... Cited by 72 - Related articles - BL Direct - All 13 versions
JJ Meier, MA Nauck - Diabetes/Metabolism Reviews - interscience.wiley.com Post-translational proteolytic processing of the preproglucagon gene in the gut
results in the formation of glucagon-like peptide 1 (GLP-1). Owing to its
glucose-dependent insulinotropic effect, this hormone was postulated to ... Cited by 71 - Related articles - All 3 versions
- ►endojournals.org WL Suarez-Pinzon, JRT Lakey, SJ Brand, A … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Pancreatic islet transplantation is a viable treatment for type 1 diabetes, but
is limited by human donor tissue availability. The combination of epidermal
growth factor (EGF) and gastrin induces islet ß-cell neogenesis from ... Cited by 68 - Related articles - All 5 versions
R Gao, J Ustinov, O Korsgren, T Otonkoski - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The neogenesis of islets from cultured human adult
pancreatic tissue has been reported. The islet progenitors have been thought to
be ductal cells. Since previous experiments have been 'contaminated' by a ... Cited by 43 - Related articles - BL Direct - All 5 versions
