- ►diabetesjournals.org R Nesher, E Anteby, M Yedovizky, N Warwar, … - Diabetes, 2002 - Am Diabetes Assoc A full biphasic insulin response is the most sensitive index for well-coupled
β-cell signal transduction. While first-phase insulin response is extremely
sensitive to potentiating and inhibiting modulations, full expression of ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org N Kaiser, R Nesher, MY Donath, M Fraenkel, V … - Diabetes, 2005 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and progressive ß-cell
failure. Deficient insulin secretion, with increased proportions of insulin
precursor molecules, is a common feature of type 2 diabetes; this could ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org N Warwar, S Efendic, CG Östenson, EP Haber … - Diabetes, 2006 - Am Diabetes Assoc Glucose metabolism affects most major signal pathways in pancreatic β-cells.
Multiple protein kinases, including protein kinase C (PKC) isoenzymes, are
involved in these effects; however, their role is poorly defined. Moreover, ... Cited by 19 - Related articles - BL Direct - All 5 versions
JAG Pertusa, R Nesher, N Kaiser, E Cerasi, … - Diabetes, 2002 - Am Diabetes Assoc When fed a high-energy (HE) diet, diabetes-prone (DP) Psammomys obesus develop
type 2 diabetes with altered glucose-stimulated insulin secretion (GSIS).
β-Cell stimulus-secretion coupling was investigated in islets isolated ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►physiology.org SM Katzman, MA Messerli, DT Barry, A … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The cells within the intact islet of Langerhans function as a metabolic
syncytium, secreting insulin in a coordinated and oscillatory manner in response
to external fuel. With increased glucose, the oscillatory amplitude is ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org TS McQuaid, MC Saleh, JW Joseph, A … - Journal of Endocrinology, 2006 - Soc Endocrinology We investigated whether an increase in cAMP could normalize glucose-stimulated
insulin secretion (GSIS) in uncoupling protein-2 (UCP2) overexpressing (ucp2-OE)
ß-cells. Indices of ß-cell (ß-TC-6f7 cells and rodent islets) function ... Cited by 7 - Related articles - BL Direct - All 5 versions
V Attali, M Parnes, Y Ariav, E Cerasi, N Kaiser … - Endocrinology, 2006 - Endocrine Soc Succinate stimulates insulin secretion and proinsulin biosynthesis. We studied
the effects of reduced nicotinamide adenine dinucleotide phosphate
(NADPH)-modulating pathways on glucose- and succinate-stimulated insulin ... Cited by 5 - Related articles - BL Direct - All 4 versions
N Warwar, A Dov, E Abramovitch, R Wu, M … - BBA-Molecular Cell Research, 2008 - Elsevier Endocrine cells produce large amounts of one or more peptides. The
post-translational control of selective production of a single protein is often
unknown. We used 3 unrelated approaches to diminish PKCε in rat islets to ... Cited by 1 - Related articles - All 2 versions
I RESPONSE - Diabetes, 2002 - Am Diabetes Assoc A full biphasic insulin response is the most sensitive index for well-coupled
-cell signal transduction. While first-phase insulin response is extremely
sensitive to potentiating and inhibiting modulations, full expression of ... Related articles - All 2 versions
JC Jonas, M Bensellam, J Duprez, H Elouil, Y … - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com Pancreatic β-cells exposed to high glucose concentrations display altered gene
expression, function, survival and growth that may contribute to the slow
deterioration of the functional β-cell mass in type 2 diabetes. These ... Related articles - All 2 versions
