- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for
causing insulin resistance and pancreatic ß-cell failure and the precise
sequence of events leading to the development of type 2 diabetes are not ... Cited by 525 - Related articles - BL Direct - All 6 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrinology, 2002 - Endocrine Soc Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on
ß-cell function, respectively referred to as glucotoxicity and lipotoxicity.
Over time, both contribute to the progressive deterioration of glucose ... Cited by 329 - Related articles - BL Direct - All 4 versions
RP Robertson - Journal of Biological Chemistry, 2004 - ASBMB Glucose in chronic excess causes toxic effects on structure and function of
organs, including the pancreatic islet. Multiple biochemical pathways and
mechanisms of action for glucose toxicity have been suggested. These ... Cited by 223 - Related articles - BL Direct - All 6 versions
RP Robertson, J Harmon, POT Tran, V Poitout - Diabetes, 2004 - Am Diabetes Assoc The relentless decline in β-cell function frequently observed in type 2
diabetic patients, despite optimal drug management, has variously been
attributed to glucose toxicity and lipotoxicity. The former theory posits ... Cited by 202 - Related articles - BL Direct - All 5 versions
M Prentki, E Joly, W El-Assaad, R Roduit - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is considered to be in most cases a polygenic disease with a
strong involvement of environmental factors, such as diet and exercise (1).
Glucose intolerance in association with hyperinsulinemia and insulin ... Cited by 177 - Related articles - BL Direct - All 3 versions
D Melloul, S Marshak, E Cerasi - Diabetologia, 2002 - Springer Insulin, synthesized by the beta cells of pancreatic is- lets, is of major
physiological importance in metabolic homeostasis. While mature insulin consists
of two polypeptide chains joined by disulphide bridges, the gene encodes ... Cited by 170 - Related articles - BL Direct - All 3 versions
CE Wrede, LM Dickson, MK Lingohr, I Briaud … - Journal of Biological Chemistry, 2002 - ASBMB Free fatty acids (FFA) have been reported to reduce pancreatic -cell mitogenesis
and to increase apoptosis. Here we show that the FFA, oleic acid, increased
apoptosis 16-fold in the pancreatic -cell line, INS-1, over a 18-h period ... Cited by 127 - Related articles - BL Direct - All 6 versions
SE Kahn - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc The pathogenesis of type 2 diabetes is complex and in most instances clearly
requires defects in both ß-cell function and insulin sensitivity (1). Together,
these abnormalities result in increased rates of glucose release by the ... Cited by 126 - Related articles - All 3 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
J Buteau, W El-Assaad, CJ Rhodes, L … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a
potential therapeutic agent in the treatment of diabetes, activates
phosphatidylinositol-3 kinase/protein kinase B signalling in the pancreatic ... Cited by 113 - Related articles - BL Direct - All 4 versions
