- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological …, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided by Laidlaw in
1938 who used the term nesidioblastosis to describe the severe, recurrent hypoglycemia associated
with an inappropriate elevation of serum insulin, C-peptide, and proinsulin (161). While ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►adisonline.com [PDF] M Rendell - Drugs, 2004 - ingentaconnect.com The sulphonylureas act by triggering insulin release from the pancreatic β cell. Abstract A specific
site on the adenosine triphosphate (ATP)-sensitive potassium channels is occupied by sulphonylureas
leading to closure of the potassium channels and subsequent opening of calcium ... Cited by 87 - Related articles - BL Direct - All 7 versions
- ►physiology.org H Huopio, SL Shyng, T Otonkoski, CG … - American Journal of …, 2002 - Am Physiological Soc ATP-sensitive potassium (K ATP ) channels are inhibited by intracellular ATP and activated by
ADP. Nutrient oxidation in -cells leads to a rise in [ATP]-to-[ADP] ratios, which in turn leads to
reduced K ATP channel activity, depolarization, voltage-dependent Ca 2+ channel ... Cited by 61 - Related articles - BL Direct - All 6 versions
- ►endojournals.org CA Stanley, PS Thornton, A Ganguly, C … - Journal of Clinical …, 2004 - Endocrine Soc INFANTS WITH CONGENITAL hyperinsulinism frequently present in the neonatal period with
symptomatic hypoglycemia, which may cause seizures or permanent brain damage. In the
past, these infants were believed to have a disturbance in pancreatic development ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Henquin, N Ishiyama, M Nenquin, MA Ravier, JC … - Diabetes, 2002 - Am Diabetes Assoc Rapid and sustained stimulation of β-cells with glucose induces biphasic insulin secretion. The
two phases appear to reflect a characteristic of stimulus-secretion coupling in each β-cell rather
than heterogeneity in the time-course of the response between β-cells or islets. There is ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org PS Thornton, C MacMullen, A Ganguly, E Ruchelli, L … - Diabetes, 2003 - Am Diabetes Assoc Recessive mutations of sulfonylurea receptor 1 (SUR1) and potassium inward rectifier 6.2
(Kir6.2), the two adjacent genes on chromosome 11p that comprise the β-cell plasma membrane
ATP-sensitive K + (K ATP ) channels, are responsible for the most common form of ... Cited by 51 - Related articles - BL Direct - All 4 versions
C Li, C Buettger, J Kwagh, A Matter, Y Daikhin, IB … - Journal of Biological …, 2004 - ASBMB Children with hypoglycemia due to recessive loss of function mutations of the β-cell ATP-sensitive
potassium (K ATP ) channel can develop hypoglycemia in response to protein feeding. We hypothesized
that amino acids might stimulate insulin secretion by unknown mechanisms, because the ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org SG Straub, KE Cosgrove, C Ämmälä, RM Shepherd, … - Diabetes, 2001 - Am Diabetes Assoc From the Institute of Molecular Physiology and Department of Biomedical Science (KEC,
RMS, REO, PDB, JCC, MJD), University of Sheffield, Western Bank, Sheffield, and the Institute
of Child Health (MS, KJL, AA-G.), London, UK; the Division of Endocrinology & ... Cited by 46 - Related articles - BL Direct - All 4 versions
O Tschritter, M Stumvoll, F Machicao, M Holzwarth, M … - Diabetes, 2002 - Am Diabetes Assoc Genetic factors play an important role in the pathogenesis of type 2 diabetes. The relevance
to type 2 diabetes of the common polymorphism Glu23Lys in the potassium inward rectifier 6.2
(KIR6.2) gene is still controversial. The aim of this study was to assess whether this ... Cited by 44 - Related articles - BL Direct - All 5 versions
OT Hardy, M Hernandez-Pampaloni, JR Saffer, M … - The Journal of Pediatrics, 2007 - Elsevier The diagnosis of focal or diffuse hyperinsulinism was correct in 23 of the 24 cases (96%) and
equivocal in 1 case. [ 18 F]-DOPA PET identified focal areas of high uptake of radiopharmaceutical
in 11 patients. Pathology results confirmed that all 11 had focal adenomatosis, and the ... Cited by 45 - Related articles - All 14 versions
