- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by
triggering and amplifying pathways. By closing ATP-sensitive K + channels (K ATP
channels) in the plasma membrane, glucose and other metabolized nutrients ... Cited by 37 - Related articles - BL Direct - All 4 versions
I Rustenbeck - Biochemical pharmacology, 2002 - Elsevier Desensitization of insulin secretion describes a reversible state of decreased
secretory responsiveness of the pancreatic β-cell, induced by a prolonged
exposure to a multitude of stimuli. These include the main physiological ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org RA Velliquette, P Ernsberger - Journal of Pharmacology and Experimental …, 2003 - ASPET We examined glucose metabolism after I 1 -imidazoline (I 1 R) and 2 -adrenergic
receptor ( 2 AR) activation in an animal model of metabolic syndrome X. Fasted
spontaneously hypertensive obese rats (SHROB) were given the I 1 R/ 2 AR ... Cited by 17 - Related articles - BL Direct - All 3 versions
I Rustenbeck, A Krautheim, A Jörns, HJ … - Biochemical pharmacology, 2004 - Elsevier A prolonged exposure of isolated pancreatic islets to insulin secretagogues, the
imidazolines phentolamine, alinidine and idazoxan (100 μM each), the
sulfonylurea tolbutamide (500 μM), or the alkaloid quinine (100 μM) ... Cited by 12 - Related articles - All 4 versions
C Bleck, A Wienbergen, I Rustenbeck - Diabetes, 2004 - Am Diabetes Assoc The glucose dependence of the insulinotropic action of K ATP channel–blocking
imidazoline compounds was investigated. Administration of 100 μmol/l
phentolamine, but not 100 μmol/l efaroxan, markedly increased insulin ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►nih.gov GD Prell, GP Martinelli, GR Holstein, J … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences We identified the previously unknown structures of ribosylated imidazoleacetic
acids in rat, bovine, and human tissues to be imidazole-4-acetic acid-ribotide
(IAA-RP) and its metabolite, imidazole-4-acetic acid-riboside. We also ... Cited by 9 - Related articles - BL Direct - All 9 versions
SLF Chan, LK Monks, H Gao, P Deaville, NG … - British Journal of Pharmacology, 2002 - pubmedcentral.nih.gov Using these antisera in an expression cloning strategy we have identified a
monomeric GTP-binding protein, Rhes, as a potential target for regulation by
imidazoline ligands. Rhes is shown to be expressed in β-cells and its ... Cited by 9 - Related articles - BL Direct - All 5 versions
C Bleck, A Wienbergen, I Rustenbeck - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Imidazolines are a class of investigational
antidiabetic drugs. It is still unclear whether the imidazoline ring is decisive
for insulinotropic char- acteristics. Materials and methods: We studied the ... Cited by 9 - Related articles - BL Direct - All 4 versions
P Ernsberger, RJ Koletsky - Naunyn-Schmiedeberg's Archives of Pharmacology, 2006 - Springer Abstract Reports of beneficial, neutral and adverse impacts of antihypertensive
drug classes on glucose and lipid metabolism can be found in human data.
Furthermore, mechanisms for these diverse effects are often speculative and ... Cited by 8 - Related articles - BL Direct - All 3 versions
NG MORGAN, EJ COOPER, PE SQUIRES, CE … - Annals of the New York Academy of Sciences, 2003 - interscience.wiley.com Abstract: The pancreatic b-cell expresses an imidazoline-binding site that is
involved in the regulation of insulin secretion. This site is pharmacologically
atypical in comparison with the I 1 and I 2 sites described in other ... Cited by 7 - Related articles - BL Direct - All 4 versions
