- ►cell.com DH Kim, DD Sarbassov, SM Ali, JE King, RR … - Cell, 2002 - Elsevier Increasing evidence indicates that in eukaryotes, cell growth (mass
accumulation) is finely regulated in response to environmental and developmental
conditions and can be deranged in human diseases such as cancer and ... Cited by 599 - Related articles - All 16 versions
- ►umn.edu [PDF] DD Sarbassov, SM Ali, DH Kim, DA Guertin, … - Current biology, 2004 - Elsevier The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived
signals to regulate growth, the process whereby cells accumulate mass and
increase in size. mTOR is a large protein kinase and the target of ... Cited by 469 - Related articles - All 21 versions
- ►bmj.com S Johnson - British Medical Journal, 1999 - thorax.bmj.com Much of our knowledge of this unusual disorder is anecdotal, coming from case
reports and reviews of patients attending tertiary referral centres, which may
not represent the full spectrum of the disease. This will change over the ... Cited by 212 - Related articles - BL Direct - All 15 versions
- ►oxfordjournals.org S Vignot, S Faivre, D Aguirre, E Raymond - Annals of Oncology, 2005 - Eur Soc Med Oncology Rapamycin and its derivatives (CCI-779, RAD001 and AP23576) are immunosuppressor
macrolides that block mTOR (mammalian target of rapamycin) functions and yield
antiproliferative activity in a variety of malignancies. Molecular ... Cited by 206 - Related articles - All 5 versions
N Kimura, C Tokunaga, S Dalal, C Richardson … - Genes to cells, 2003 - Mol Biology Soc Japan 1Biosignal Research Center, Kobe University, Kobe 657-8501, Japan 2Department of
Medicine and Biochemistry, Division of Endocrinology, Diabetes and Metabolism,
Dartmouth Medical School, Hanover, New Hampshire 03755, USA 3St. Vincent's ... Cited by 150 - Related articles - BL Direct - All 5 versions
AS Greenberg, ML McDaniel - European journal of clinical investigation, 2002 - interscience.wiley.com A combination of insulin resistance and pancreatic β-cell dysfunction underlies
most cases of type 2 diabetes. While the interplay of these two impairments is
believed to be important in the development and progression of type 2 ... Cited by 144 - Related articles - BL Direct - All 4 versions
KA Martin, J Blenis - Advances in cancer research, 2002 - books.google.com Coordinate Regulation of Translation by the PI 3-Kinase and mTOR Pathways
Kathleen A. Martin and John Blenis Department of Cell Biology, Harvard Medical
School, Boston, Massachusetts 02115 I. Overview of Translational Regulatory ... Cited by 118 - Related articles - BL Direct - All 4 versions
- ►pnas.org BN Desai, BR Myers, SL Schreiber - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences FKBP12-rapamycin associated protein (FRAP, also known as mTOR or RAFT) is the
founding member of the phosphatidylinositol kinase-related kinase family and
functions as a sensor of physiological signals that regulate cell growth. ... Cited by 89 - Related articles - BL Direct - All 15 versions
C Tokunaga, K Yoshino, K Yonezawa - Biochemical and Biophysical Research …, 2004 - Elsevier The AMP-activated protein kinase (AMPK) exists as a heterotrimetric complex
comprising a catalytic α subunit and non-catalytic β and γ subunits. Under
conditions of hypoxia, exercise, ischemia, heat shock, and low glucose, ... Cited by 82 - Related articles - All 5 versions
G Xu, W Zhang, P Bertram, XF Zheng, H … - International journal of oncology, 2004 - umdnj.edu Abstract. The protein synthetic machinery is activated by a variety of genetic
alterations during tumor progression and represents an attractive target for
cancer therapy. The mammalian target of rapamycin (mTOR) plays an important ... Cited by 81 - Related articles - View as HTML - BL Direct - All 4 versions
