- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for
causing insulin resistance and pancreatic ß-cell failure and the precise
sequence of events leading to the development of type 2 diabetes are not ... Cited by 514 - Related articles - BL Direct - All 6 versions
BD Hegarty, SM Furler, J Ye, GJ Cooney, EW … - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 120 - Related articles - BL Direct - All 4 versions
NE Zachara, GW Hart - BBA-Molecular and Cell Biology of Lipids, 2006 - Elsevier An increasing body of evidence points to a central regulatory role for glucose
in mediating cellular processes and expands the role of glucose well beyond its
traditional role(s) in energy metabolism. Recently, it has been recognized ... Cited by 78 - Related articles - All 4 versions
- ►physiology.org MG Buse - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc The hexosamine biosynthesis pathway (HBP) is a relatively minor branch of
glycolysis. Fructose 6-phosphate is converted to glucosamine 6-phosphate,
catalyzed by the first and rate-limiting enzyme ... Cited by 79 - Related articles - BL Direct - All 6 versions
M Krebs, M Roden - Diabetes Obesity and Metabolism, 2005 - pt.wkhealth.com Increased body fat content correlates with insulin resistance and is a key
feature of type 2 diabetes. Excessive intake of fat results in deposition of
lipids not only in fat tissue but also in skeletal muscle and liver. ... Cited by 39 - Related articles - BL Direct - All 6 versions
C Weigert, K Klopfer, C Kausch, K Brodbeck, … - Diabetes, 2003 - Am Diabetes Assoc The nutrient sensing capacity of the hexosamine biosynthetic pathway (HBP) has
been implicated in the development of insulin resistance of skeletal muscle. To
study the molecular mechanism of the free fatty acid (FFA)-induced ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►physiology.org FN Lee, L Zhang, D Zheng, WS Choi, JH … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Starvation and experimental diabetes induce a stable increase in pyruvate
dehydrogenase kinase (PDK) activity in skeletal muscle, which is largely due to
a selective upregulation of PDK-4 expression. Increased free fatty acid ... Cited by 25 - Related articles - All 4 versions
- ►nih.gov E Ravussin - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In response to changes in environmental conditions, animals and humans alike can
initiate physiological regulatory mechanisms to assure survival. For example,
when food is scarce, the body becomes “thrifty”, and conversely, when ... Cited by 17 - Related articles - BL Direct - All 7 versions
- ►shouxi.net YI Kim, FN Lee, WS Choi, S Lee, JH Youn - Diabetes, 2006 - Am Diabetes Assoc We previously showed that insulin has a profound effect to suppress pyruvate
dehydrogenase kinase (PDK) 4 expression in rat skeletal muscle. In the present
study, we examined whether insulin's effect on PDK4 expression is impaired ... Cited by 17 - Related articles - BL Direct - All 6 versions
