- ►rockefeller.edu [PDF] JS Flier - Cell, 2004 - Elsevier The past ten years have been the golden age of obesity research. While long
understood that the amount of body weight and fat are determined by an interplay
of inheritance and environment, we are for the first time learning the ... Cited by 490 - Related articles - All 27 versions
- ►leptipro.org [PDF] C Bjorbaek, BB Kahn - Recent progress in hormone research, 2004 - Endocrine Soc The discovery of leptin in 1994 has led to astonishing advances in understanding
the regulation of energy balance in rodents and humans. The demonstration of
leptin receptors in hypothalamic regions known to play critical roles in ... Cited by 223 - Related articles - BL Direct - All 5 versions
- ►nih.gov P Cohen, C Zhao, X Cai, JM Montez, SC … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype
that is indistinguishable from that of leptin deficient ob/ob mice. ObR is
expressed in many tissues, including brain, and the relative importance of ... Cited by 214 - Related articles - BL Direct - All 9 versions
- ►leptipro.org [PDF] G Sweeney - Cellular signalling, 2002 - Elsevier The identification of leptin as the product of the obesity (ob) gene has been
followed by extensive research identifying a wide spectrum of physiological
effects elicited by this adipose-derived hormone. These effects are ... Cited by 176 - Related articles - All 10 versions
RS Ahima, SY Osei - Physiology & behavior, 2004 - Elsevier A connection between the brain and regulation of body weight was first
postulated, based on the observation that tumors encroaching on the base of the
brain caused voracious appetite, morbid obesity, hypogonadism and other ... Cited by 143 - Related articles - All 3 versions
- ►utsouthwestern.edu [PDF] H Dhillon, JM Zigman, C Ye, CE Lee, RA … - Neuron, 2006 - Elsevier Leptin, an adipocyte-derived hormone, acts directly on the brain to control food
intake and energy expenditure. An important question is the identity of
first-order neurons initiating leptin's anti-obesity effects. A widely held ... Cited by 129 - Related articles - All 21 versions
- ►cell.com R Coppari, M Ichinose, CE Lee, AE Pullen, … - Cell metabolism, 2005 - Elsevier Leptin is required for normal energy and glucose homeostasis. The hypothalamic
arcuate nucleus (ARH) has been proposed as an important site of leptin action.
To assess the physiological significance of leptin signaling in the ARH, we ... Cited by 101 - Related articles - All 12 versions
- ►nih.gov S Srinivasan, C Lubrano-Berthelier, C … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig 1 Gladstone Institute of Cardiovascular Disease, 2 Diabetes Center, and 3
Department of Cellular and Molecular Pharmacology, UCSF, San Francisco,
California, USA. ... Address correspondence to: Christian Vaisse, Diabetes ... Cited by 71 - Related articles - BL Direct - All 12 versions
- ►endojournals.org G Yang, H Ge, A Boucher, X Yu, C Li - Molecular Endocrinology, 2004 - Endocrine Soc Soluble leptin receptor (SLR) represents the major leptin binding activity in
plasma. It is generated by alternative splicing of OB-R mRNA (OB-Re) and/or
ectodomain shedding of membrane-spanning receptors. To determine the role ... Cited by 66 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org FR DeRubertis, PA Craven, MF Melhem, EM … - Diabetes, 2004 - Am Diabetes Assoc The effects of overexpression of Cu 2+ /Zn 2+ superoxide dismutase-1 (SOD-1) on
indexes of renal injury were compared in 5-month-old nontransgenic (NTg) db/db
mice and db/db mice hemizygous for the human SOD-1 transgene (SOD-Tg). Both ... Cited by 59 - Related articles - BL Direct - All 4 versions
