- ►fasebj.org NA Taylor, VEN VAN DE, JM WIM, JWM … - The FASEB Journal, 2003 - FASEB The proprotein convertases (PCs) are a seven-member family of endoproteases that
activate proproteins by cleavage at basic motifs. Expression patterns for
individual PCs vary widely, and all cells express several members. The list ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►endojournals.org RL Hull, GT Westermark, P Westermark, SE … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these
deposits contain the unique amyloidogenic peptide islet amyloid polypeptide.
Autopsy studies in humans have demonstrated that islet amyloid is ... Cited by 119 - Related articles - BL Direct - All 6 versions
ETAS Jaikaran, A Clark - BBA-Molecular Basis of Disease, 2001 - Elsevier Islet amyloid polypeptide (IAPP, amylin) is secreted from pancreatic islet
β-cells and converted to amyloid deposits in type 2 diabetes. Conversion from
soluble monomer, IAPP 1–37, to β-sheet fibrils involves changes in the ... Cited by 84 - Related articles - All 5 versions
- ►nih.gov RW Gelling, XQ Du, DS Dichmann, J Rømer, H … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic
α cells in response to low blood glucose. To examine the role of glucagon in
glucose homeostasis, mice were generated with a null mutation of the ... Cited by 80 - Related articles - BL Direct - All 7 versions
- ►nih.gov X Zhu, L Orci, R Carroll, C Norrbom, M … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences The neuroendocrine processing endoproteases PC2 and PC1/3 are expressed in the
β cells of the islets of Langerhans and participate in the processing of
proinsulin to insulin and C-peptide. We have previously shown that ... Cited by 68 - Related articles - BL Direct - All 11 versions
- ►jbc.org M Furuta, A Zhou, G Webb, R Carroll, M … - Journal of Biological Chemistry, 2001 - ASBMB Mice homozygous for a deletion in the gene encoding prohormone convertase 2
(PC2) are generally healthy but have mild hypoglycemia and flat
glucose-tolerance curves. Their islets show marked alpha (A)-cell ... Cited by 66 - Related articles - BL Direct - All 3 versions
L Marzban, K Park, CB Verchere - Experimental gerontology, 2003 - Elsevier Type 2 diabetes is associated with progressive β-cell failure manifest as a
decline in insulin secretion and increasing hyperglycemia. A growing body of
evidence suggests that β-cell failure in type 2 diabetes correlates with ... Cited by 52 - Related articles - All 5 versions
A Clark, MR Nilsson - Diabetologia, 2004 - Springer The role of islet amyloidosis in the onset and progres- sion of Type 2 diabetes
remains obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide
which is co-stored and co-released with insulin. Human islet amyloid ... Cited by 51 - Related articles - BL Direct - All 7 versions
K Park, CB Verchere - Journal of Biological Chemistry, 2001 - ASBMB Islet amyloid deposits are a characteristic pathologic lesion of the pancreas in
type 2 diabetes and are composed primarily of the islet beta cell peptide islet
amyloid polypeptide (IAPP or amylin) as well as the basement membrane ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org RL Hull, S Andrikopoulos, CB Verchere, J … - Diabetes, 2003 - Am Diabetes Assoc Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide
(hIAPP) in their islet β-cells are a model of islet amyloid formation as it
occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet ... Cited by 37 - Related articles - BL Direct - All 7 versions
