JC Henquin, MA Ravier, M Nenquin, … - … Journal of Clinical …, 2003 - journals.indexcopernicus.com logo IndexCopernicus, Current language: English. IC Journals Master List. Journal of the Week.
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E Ferrannini, A Mari - Diabetologia, 2004 - Springer The importance of both insulin resistance and beta cell dysfunction in the pathogenesis of glucose
intolerance is widely recognised. Also popular is the concept that beta cell secretory function
must be viewed in the context of extant insulin resistance. This For Debate moves from ... Cited by 76 - Related articles - BL Direct - All 4 versions
MA Ravier, M Güldenagel, A Charollais, A Gjinovci, D … - Diabetes, 2005 - Am Diabetes Assoc Normal insulin secretion requires the coordinated functioning of β-cells within pancreatic
islets. This coordination depends on a communications network that involves the interaction
of β-cells with extracellular signals and neighboring cells. In particular, adjacent β-cells ... Cited by 60 - Related articles - All 4 versions
- ►diabetesjournals.org JC Henquin, N Ishiyama, M Nenquin, MA Ravier, JC … - Diabetes, 2002 - Am Diabetes Assoc Rapid and sustained stimulation of β-cells with glucose induces biphasic insulin secretion. The
two phases appear to reflect a characteristic of stimulus-secretion coupling in each β-cell rather
than heterogeneity in the time-course of the response between β-cells or islets. There is ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Nesher, E Cerasi - Diabetes, 2002 - Am Diabetes Assoc The cellular and molecular mechanisms of insulin secretion are being intensively
investigated, yet most researchers are seemingly unaware of the complexity of the dynamic regulation
of the secretion. In this article, we summarize studies of the physiology of insulin secretion ... Cited by 55 - Related articles - BL Direct - All 5 versions
P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro are still
unclear. Because glucose metabolism and changes in cytosolic free Ca 2+ ([Ca 2+ ] c ) in β-cells
play a key role in the control of insulin secretion, and because oscillations of these two ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►nih.gov SE Samaras, MA Cissell, K Gerrish, CVE … - Molecular and Cellular …, 2002 - Am Soc Microbiol Pancreas duodenum homeobox 1 (PDX-1) is absolutely required for pancreas development
and the maintenance of islet ß-cell function. Temporal and cell-type-specific transcription of the
pdx-1 gene is controlled by factors acting upon sequences found within its 5'-flanking ... Cited by 45 - Related articles - BL Direct - All 5 versions
JC Henquin, M Nenquin, P Stiernet, B Ahren - Diabetes, 2006 - Am Diabetes Assoc The mechanisms underlying biphasic insulin secretion have not been completely
elucidated. We compared the pattern of plasma insulin changes during hyperglycemic clamps
in mice to that of glucose-induced insulin secretion and cytosolic calcium concentration ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►physiology.org I Quesada, E Fuentes, E Andreu, P Meda, … - American Journal of …, 2003 - Am Physiological Soc Pancreatic -cells constitute a well-communicating multicellular network that permits a coordinated
and synchronized signal transmission within the islet of Langerhans that is necessary for proper
insulin release. Gap junctions are the molecular keys that mediate functional cellular ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►biolcell.org [PDF] V Serre-Beinier, C Mas, A Calabrese, D Caton, J … - Biology of the Cell, 2002 - Elsevier Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine
and exocrine glands investigated so far and also connect most types of cells which produce secretory
products in other tissues. Increasing evidence indicates that connexins, and the ... Cited by 28 - Related articles - All 10 versions
