- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated
diabetes mellitus in ro- dents and possibly in humans. Clarification of the
regulation of beta-cell death could indicate novel sites for therapeutic ... Cited by 320 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Cnop, JC Hannaert, A Hoorens, DL Eizirik, … - Diabetes, 2001 - Am Diabetes Assoc Studies in Zucker diabetic fatty rats have led to the concept that chronically
elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden
pancreatic β-cells as a result of the formation of ceramides, which induce ... Cited by 216 - Related articles - BL Direct - All 9 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
JD Piganelli, SC Flores, C Cruz, J Koepp, I … - Diabetes, 2002 - Am Diabetes Assoc We present here the first report of a metalloporphyrin-based antioxidant that
can prevent or delay the onset of autoimmune diabetes. Type 1 diabetes is an
autoimmune process whereby T-cells recognize pancreatic β-cell antigens ... Cited by 84 - Related articles - BL Direct - All 4 versions
I Rakatzi, H Mueller, O Ritzeler, N Tennagels, … - Diabetologia, 2004 - Springer Aims/hypothesis. Pancreatic beta-cell apoptosis is a common feature of Type 1
and Type 2 diabetes and leptin exerts an anti-apoptotic function in these cells.
The beta-cell line INS-1 was used to test the hypothe- sis that the ... Cited by 83 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, S Bertera, M … - Diabetes, 2002 - Am Diabetes Assoc The most commonly used technical approach to isolate human pancreatic islets
intended for allotransplants generates a product that is hampered by mechanical
and chemical insults, which dramatically reduce the mass of viable and ... Cited by 79 - Related articles - BL Direct - All 5 versions
HE Thomas, R Darwiche, JA Corbett, TWH … - Diabetes, 2002 - Am Diabetes Assoc Cytokines have been implicated in pancreatic β-cell destruction leading to type
1 diabetes. In vitro, a combination of γ-interferon (IFN-γ) and interleukin-1
(IL-1) stimulate inducible nitric oxide synthase (iNOS) expression in ... Cited by 76 - Related articles - BL Direct - All 6 versions
- ►pasteur.ac.ir [PDF] P Santamaria - Current Opinion in Immunology, 2001 - Elsevier Autoimmune diseases result from complex interactions among different T- and
B-lymphocyte subpopulations that target a rapidly growing number of autoantigens
on different cell types. The etiology of most spontaneous autoimmune ... Cited by 62 - Related articles - BL Direct - All 8 versions
- ►nih.gov R Eldor, A Yeffet, K Baum, V Doviner, D Amar, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Type 1 diabetes is characterized by the infiltration of inflammatory cells into
pancreatic islets of Langerhans, followed by the selective and progressive
destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes ... Cited by 50 - Related articles - BL Direct - All 8 versions
- ►pubget.com [PDF] HE Thomas, R Darwiche, JA Corbett, TW Kay - Diabetes, 2002 - Am Diabetes Assoc Cytokines have been implicated in pancreatic -cell destruction leading to type 1
diabetes. In vitro, a com- bination of -interferon (IFN- ) and interleukin-1
(IL-1) stimulate inducible nitric oxide synthase (iNOS) expression in ... Cited by 30 - Related articles - All 2 versions
