- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance
and pancreatic ß-cell failure and the precise sequence of events leading to the development
of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and ... Cited by 525 - Related articles - BL Direct - All 6 versions
CE Wrede, LM Dickson, MK Lingohr, I Briaud, CJ … - Journal of Biological …, 2002 - ASBMB Free fatty acids (FFA) have been reported to reduce pancreatic -cell mitogenesis and to increase
apoptosis. Here we show that the FFA, oleic acid, increased apoptosis 16-fold in the pancreatic
-cell line, INS-1, over a 18-h period as assessed by Hoechst 33342/propidium iodide ... Cited by 127 - Related articles - BL Direct - All 6 versions
- ►endocrinology-journals.org [PDF] SE Ozanne, GS Olsen, LL Hansen, KJ … - Journal of …, 2003 - Soc Endocrinology Epidemiological studies have revealed a relationship between early growth restriction and the
subsequent development of type 2 diabetes. A rat model of maternal protein restriction has been
used to investigate the mech- anistic basis of this relationship. This model causes insulin ... Cited by 87 - Related articles - BL Direct - All 5 versions
- ►cell.com S Neschen, K Morino, LE Hammond, D Zhang, ZX Liu, … - Cell metabolism, 2005 - Elsevier In order to investigate the role of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase
1 (mtGPAT1) in the pathogenesis of hepatic steatosis and hepatic insulin resistance, we examined
whole-body insulin action in awake mtGPAT1 knockout (mtGPAT1 −/− ) and wild-type (wt) ... Cited by 77 - Related articles - All 10 versions
C Schmitz-Peiffer - ANNALS-NEW YORK ACADEMY OF …, 2002 - interscience.wiley.com Abstract: Insulin resistance of skeletal muscle in humans, animals, and cells is often strongly
correlated with increased lipid availability. The elevation of certain intracellular lipid species
can lead to the activation of signal transduction pathways that inhibit normal insulin ... Cited by 75 - Related articles - BL Direct - All 5 versions
I Raz, R Eldor, S Cernea, E Shafrir - Diabetes/Metabolism Reviews - interscience.wiley.com We present multiple findings on derangements in lipid metabolism in type 2 diabetes. The increase
in the intracellular deposition of triglycerides (TG) in muscles, liver and pancreas in subjects
prone to diabetes is well documented and demonstrated to attenuate glucose metabolism ... Cited by 71 - Related articles - All 3 versions
E Shafrir, E Ziv, L Mosthaf - ANNALS-NEW YORK ACADEMY OF …, 1999 - interscience.wiley.com ABSTRACT: Animals with genetically or nutritionally induced insulin resistance and Type 2 diabetes
comprise two groups: those with resilient β-cells, eg, ob/ob mice or fa/fa rats, capable of longstanding
compensatory insulin hypersecretion and those with labile β-cells in which the secretion ... Cited by 50 - Related articles - BL Direct - All 5 versions
I Briaud, LM Dickson, MK Lingohr, JF McCuaig, JC … - Journal of Biological …, 2005 - ASBMB Regulation of insulin receptor substrate (IRS)-2 expression is critical to β-cell survival, but the
mechanisms that control this are complex and undefined. Here in pancreatic β-cells (INS-1),
chronic exposure (>8 h) to 15 mm glucose and/or 5 nm IGF-1, increased Ser/Thr ... Cited by 44 - Related articles - All 5 versions
- ►ajcn.org MP Corcoran, S Lamon-Fava, RA … - American Journal of …, 2007 - Am Soc Nutrition Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations are
associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation is most
likely due to enhanced fatty acid uptake into the muscle coupled with diminished ... Cited by 36 - Related articles - BL Direct - All 12 versions
RK Avramoglu, W Qiu, K Adeli - Front Biosci, 2003 - bioscience.org 1. Abstract 2. Deregulation of Lipoprotein Metabolism in Insulin Resistant States 2.1. Metabolic
dyslipidemia in insulin resistance 2.2. Insulin regulation of apoB-containing lipoproteins 2.3.
The hepatic insulin signaling pathway and disruption in insulin resistance 2.4. Animal ... Cited by 35 - Related articles - View as HTML - All 3 versions
