- ►endojournals.org RT Watson, M Kanzaki, JE Pessin - Endocrine reviews, 2004 - Endocrine Soc Since the discovery of insulin roughly 80 yr ago, much has been learned about how target cells
receive, interpret, and respond to this peptide hormone. For example, we now know that insulin
activates the tyrosine kinase ... Cited by 186 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org D Konrad, PJ Bilan, Z Nawaz, G Sweeney, W Niu, Z Liu … - Diabetes, 2002 - Am Diabetes Assoc There is a need to understand whether the amount of GLUT4 at the cell surface determines the extent
of glucose uptake in response to insulin. Thus, we created a heterozygous mouse expressing modest
levels of myc-tagged GLUT4 ... Cited by 49 - Related articles - BL Direct - All 6 versions
JT Brozinick, ED Hawkins, AB Strawbridge, JS … - Journal of Biological …, 2004 - ASBMB Cell culture work suggests that signaling to polymerize cortical filamentous actin (F-actin)
represents a required pathway for the optimal redistribution of the insulin-responsive glucose
transporter, GLUT4, to the plasma ... Cited by 37 - Related articles - BL Direct - All 6 versions
RT Watson, JE Pessin - Cellular Signalling, 2007 - Elsevier Insulin regulates circulating glucose levels by suppressing hepatic glucose production and
increasing glucose transport into muscle and adipose tissues. Defects in these processes are
associated with elevated vascular ... Cited by 29 - Related articles - All 4 versions
H Wallberg-Henriksson, JR Zierath - Molecular Membrane …, 2001 - informahealthcare.com Summary Studies in which GLUT4 has been overexpressed in transgenic mice provide definitive evidence
that glucose transport is rate limiting for muscle glucose disposal. Transgenic overexpression of
GLUT4 selectively in skeletal ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►nih.gov M Funaki, P Randhawa, PA Janmey - Molecular and Cellular Biology, 2004 - Am Soc Microbiol GLUT4 (glucose transporter 4) plays a pivotal role in insulin-induced glucose uptake to maintain
normal blood glucose levels. Here, we report that a cell-permeable phosphoinositide-binding peptide
induced GLUT4 translocation to the ... Cited by 24 - Related articles - BL Direct - All 7 versions
- ►physiology.org R Carroll, AN Carley, JRB Dyck, DL … - American Journal of …, 2005 - Am Physiological Soc Diabetic db/db mice exhibit profound insulin resistance in vivo, but the specific degree of cardiac
insensitivity to insulin has not been assessed. Therefore, the effect of insulin on cardiomyocytes
from db/db hearts was assessed by ... Cited by 24 - Related articles - All 4 versions
SS Im, SK Kwon, SY Kang, TH Kim, HI Kim, … - Biochemical …, 2006 - pubmedcentral.nih.gov Expression of the GLUT4 (glucose transporter type 4 isoform) gene in adipocytes is subject to
hormonal or metabolic control. In the present study, we have characterized an adipose tissue
transcription factor that is ... Cited by 14 - Related articles - BL Direct - All 8 versions
- ►physiology.org AD Hafstad, GH Solevag, DL Severson, … - American Journal of …, 2006 - Am Physiological Soc Diabetic (db/db) mice provide an animal model of Type 2 diabetes characterized by marked in vivo
insulin resistance. The effect of insulin on myocardial metabolism has not been fully elucidated in
this diabetic model. In the present ... Cited by 14 - Related articles - All 3 versions
CJ Carlson, CM Rondinone - Metabolism, 2005 - Elsevier Inhibition of p38, a member of the mitogen-activated protein kinase family, has been shown to
prevent the loss of GLUT4 protein expression in insulin-resistant adipocytes without improving
insulin receptor substrate 1 ... Cited by 8 - Related articles - All 6 versions
