- ►sciencesignaling.org [PDF] J Grimsby, R Sarabu, WL Corbett, NE Haynes, … - Science, 2003 - sciencemag.org Page 1. DOI: 10.1126/science.1084073 , 370 (2003); 301 Science et al. Joseph Grimsby,
in Diabetes Therapy Allosteric Activators of Glucokinase: Potential Role ... Cited by 186 - Related articles - All 12 versions
- ►psu.edu [PDF] M Guerre-Millo, C Rouault, P Poulain, J André … - Diabetes, 2001 - Am Diabetes Assoc Peroxisome proliferator–activated receptor (PPAR)-α controls the expression
of genes involved in lipid metabolism. PPAR-α furthermore participates to
maintain blood glucose during acute metabolic stress, as shown in ... Cited by 135 - Related articles - BL Direct - All 6 versions
UJ Desai, ED Slosberg, BR Boettcher, SL … - Diabetes, 2001 - Am Diabetes Assoc Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose
metabolism. Hepatic glucokinase (GK) is an important regulator of glucose
storage and disposal in the liver. GK levels are lowered in patients with ... Cited by 63 - Related articles - BL Direct - All 5 versions
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►alfediam.org [PDF] C Postic, R Dentin, J Girard - Diabetes and Metabolism, 2004 - Elsevier The liver plays a unique role in controlling carbohydrate metabolism by
maintaining glucose concentrations in a normal range over both short and long
periods of times. In type 2 diabetes, alterations in hepatic glucose ... Cited by 47 - Related articles - All 4 versions
T Ferre, E Riu, S Franckhauser, J Agudo, F … - Diabetologia, 2003 - Springer Aims/hypothesis. Glucokinase overexpression in the liver increases glucose
uptake and utilization, and im- proves glucose tolerance in young transgenic
mice. Here, we examined the long-term effects of hepatic overexpression of ... Cited by 26 - Related articles - BL Direct - All 3 versions
J Grimsby, FM Matschinsky, JF Grippo - Glucokinase and Glycemic Disease: From Basics to … - books.google.com Fig. 3. Close-up of GKA binding site showing amino acid residues making direct
interactions with a GKA. Mutations in V62, M210 and M235 cause the MODY-2 pheno-
type whereas V455M, A456V and Y214A mutations increase the catalytic ... Cited by 21 - Related articles - BL Direct - All 3 versions
L Chan, M Fujimiya, H Kojima - Trends in Molecular Medicine, 2003 - Elsevier Gene therapy has been hyped as a possible 'cure' for diabetes mellitus in the
near future ever since insulin was first cloned and expressed in cultured cells
in the late 1970s. In the past decade, however, the bar for gene therapy ... Cited by 19 - Related articles - All 3 versions
- ►endojournals.org JJ Collier, DK Scott - Molecular Endocrinology, 2004 - Endocrine Soc The liver is responsible for glucose synthesis in the fasting state, and glucose
uptake, storage, and utilization in the fed state. A phenotypic switch, normally
initiated by insulin or glucagon, controls the transition between the two ... Cited by 18 - Related articles - BL Direct - All 8 versions
P Dunterf, A Swain, U Kammlotf, R Crowther, … - Glucokinase and glycemic diseases: from basics to …, 2004 - books.google.com Matschinsky FM, Magnuson MA (eds): Glucokinase and Glycemic Disease: From Basics
to Novel Therapeutics. Front Diabetes. Basel, Karger, 2004, vol 16, pp 145-154
Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule ... Cited by 17 - Related articles - All 4 versions
